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ZBTB14 zinc finger and BTB domain containing 14 [ Homo sapiens (human) ]

Gene ID: 7541, updated on 21-Dec-2019

Summary

Official Symbol
ZBTB14provided by HGNC
Official Full Name
zinc finger and BTB domain containing 14provided by HGNC
Primary source
HGNC:HGNC:12860
See related
Ensembl:ENSG00000198081 MIM:602126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZF5; ZFP-5; ZFP161; ZNF478; ZFP-161
Expression
Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See ZBTB14 in Genome Data Viewer
Location:
18p11.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (5289019..5297053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (5289018..5297052, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene transforming acidic coiled-coil containing protein 3 pseudogene Neighboring gene long intergenic non-protein coding RNA 526 Neighboring gene long intergenic non-protein coding RNA 667 Neighboring gene uncharacterized LOC107985144 Neighboring gene uncharacterized LOC105371970

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126126

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cardiac septum development IEA
Inferred from Electronic Annotation
more info
 
coronary vasculature development IEA
Inferred from Electronic Annotation
more info
 
heart valve development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
aggresome IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 14
Names
ZFP161 zinc finger protein
zinc finger protein 161 homolog
zinc finger protein 478
zinc finger protein 5 homolog
zinc finger protein homologous to Zfp161 in mouse

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143823.3NP_001137295.1  zinc finger and BTB domain-containing protein 14

    See identical proteins and their annotated locations for NP_001137295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AP001496, AW338628, BC057282
    Consensus CDS
    CCDS11837.1
    UniProtKB/Swiss-Prot
    O43829
    Related
    ENSP00000349503.4, ENST00000357006.8
    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  2. NM_001243702.2NP_001230631.1  zinc finger and BTB domain-containing protein 14

    See identical proteins and their annotated locations for NP_001230631.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AP001496, AW338628, BI561601
    Consensus CDS
    CCDS11837.1
    UniProtKB/Swiss-Prot
    O43829
    Related
    ENSP00000499212.1, ENST00000651870.1
    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  3. NM_001243704.1NP_001230633.1  zinc finger and BTB domain-containing protein 14

    See identical proteins and their annotated locations for NP_001230633.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AP001496, AW338628, DB442630
    Consensus CDS
    CCDS11837.1
    UniProtKB/Swiss-Prot
    O43829
    Related
    ENSP00000484129.1, ENST00000614697.4
    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  4. NM_003409.5NP_003400.2  zinc finger and BTB domain-containing protein 14

    See identical proteins and their annotated locations for NP_003400.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK313236, AP001496, AW338628
    Consensus CDS
    CCDS11837.1
    UniProtKB/Swiss-Prot
    O43829
    UniProtKB/TrEMBL
    B2R850
    Related
    ENSP00000383009.3, ENST00000400143.7
    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    5289019..5297053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451266.1XP_024307034.1  zinc finger and BTB domain-containing protein 14 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  2. XM_024451262.1XP_024307030.1  zinc finger and BTB domain-containing protein 14 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  3. XM_024451264.1XP_024307032.1  zinc finger and BTB domain-containing protein 14 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  4. XM_024451261.1XP_024307029.1  zinc finger and BTB domain-containing protein 14 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  5. XM_024451265.1XP_024307033.1  zinc finger and BTB domain-containing protein 14 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
  6. XM_024451263.1XP_024307031.1  zinc finger and BTB domain-containing protein 14 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:303383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:319344
    zf-H2C2_2; Zinc-finger double domain
    cd18204
    Location:18131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
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