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gck glucokinase (hexokinase 4) [ Danio rerio (zebrafish) ]

Gene ID: 751668, updated on 19-Jun-2024

Summary

Official Symbol
gckprovided by ZNC
Official Full Name
glucokinase (hexokinase 4)provided by ZNC
Primary source
ZFIN:ZDB-GENE-060825-204
See related
Ensembl:ENSDARG00000068006 AllianceGenome:ZFIN:ZDB-GENE-060825-204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
glk; hex4; fb57f10; wu:fb57f10; zgc:153643
Summary
Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See gck in Genome Data Viewer
Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (40477264..40490579)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (40437679..40450994)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 10Aa Neighboring gene myosin, light chain 7, regulatory Neighboring gene sb:cb288 Neighboring gene NPC1-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC153643

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables D-glucose binding IEA
Inferred from Electronic Annotation
more info
 
enables fructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables hexokinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables mannokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in carbohydrate phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular glucose homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within intracellular glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pancreas regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
hexokinase-4
Names
glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
NP_001038850.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045385.2NP_001038850.2  hexokinase-4

    Status: VALIDATED

    Source sequence(s)
    BX248505, FO904822
    UniProtKB/TrEMBL
    A0A8M1NAW0, F1RC38
    Related
    ENSDARP00000112428.2, ENSDART00000129772.3
    Conserved Domains (3) summary
    COG5026
    Location:26468
    COG5026; Hexokinase [Carbohydrate transport and metabolism]
    pfam00349
    Location:26225
    Hexokinase_1; Hexokinase
    pfam03727
    Location:231465
    Hexokinase_2; Hexokinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    40477264..40490579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)