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TYR tyrosinase [ Felis catus (domestic cat) ]

Gene ID: 751100, updated on 5-Aug-2026
Official Symbol
TYR
Official Full Name
tyrosinase
Primary source
VGNC:VGNC:66738
See related
Ensembl:ENSFCTG00005016519
Gene type
protein coding
RefSeq status
MODEL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
all
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Try the new Transcripts and proteins table
See TYR in Genome Data Viewer
Location:
chromosome: D1
Exon count:
6
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) D1 NC_058377.1 (43917548..44023716, complement)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) D1 NC_018732.3 (45803122..45908743, complement)

Chromosome D1 - NC_058377.1Genomic Context describing neighboring genes Neighboring gene Putative N-acetylated-alpha-linked acidic dipeptidase Neighboring gene NADPH oxidase 4 Neighboring gene uncharacterized LOC123380451 Neighboring gene U2 spliceosomal RNA Neighboring gene glutamate metabotropic receptor 5 Neighboring gene tigger transposable element-derived protein 1-like

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mocha tyrosinase variant: a new flavour of cat coat coloration. Yu Y, et al. Anim Genet, 2019 Apr. PMID 30716167, Free PMC Article
  2. Cutaneous malignant melanomas in 57 cats: identification of (amelanotic) signet-ring and balloon cell types and verification of their origin by immunohistochemistry, electron microscopy, and in situ hybridization. van der Linde-Sipman JS, et al. Vet Pathol, 1997 Jan. PMID 9150543
  3. Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci. Schmidt-Küntzel A, et al. J Hered, 2005 Jul-Aug. PMID 15858157
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This findings of this study suggest that TYR is associated with the novel mocha coloration in cats.
    Title: Mocha tyrosinase variant: a new flavour of cat coat coloration.
  2. Specific nucleotide variants of feline TYR(chromosome D1) are causative of the siamese (c(s)) and burmese (c(b)) alleles of the albino locus.
    Title: Tyrosinase and tyrosinase related protein 1 alleles specify domestic cat coat color phenotypes of the albino and brown loci.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables tyrosinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in melanin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pigmentation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
tyrosinase
Names
monophenol monooxygenase
XP_003992691.3
XP_044894569.1

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058377.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    43917548..44023716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003992642.5 → XP_003992691.3  tyrosinase isoform X1

    UniProtKB/Swiss-Prot
    A0A0A0MQ28, P55033, Q2VPV8
    UniProtKB/TrEMBL
    A0ABI7YHM6
    Related
    ENSFCTP00005034065.1, ENSFCTT00005047354.1
    Conserved Domains (2) summary
    pfam00264
    Location:171 → 403
    Tyrosinase; Common central domain of tyrosinase
    cl21504
    Location:88 → 109
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

  2. XM_045038634.1 → XP_044894569.1  tyrosinase isoform X2

    UniProtKB/Swiss-Prot
    A0A0A0MQ28, P55033, Q2VPV8
    UniProtKB/TrEMBL
    A0ABI7YGT9
    Related
    ENSFCTP00005034017.1, ENSFCTT00005047298.1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P55033.2 GenPept UniProtKB/Swiss-Prot:P55033

Gene LinkOut

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Molecular Biology Databases
Research Materials