Ube2dnl2 ubiquitin-conjugating enzyme E2D N-terminal like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2dnl2provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2D N-terminal like 2provided by MGI
Primary source: MGI:MGI:1922347
See related: Ensembl:ENSMUSG00000047079 AllianceGenome:MGI:1922347
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4930524E20Rik
Summary: Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in protein polyubiquitination. Predicted to be active in nucleus. Is expressed in dorsal root ganglion; heart ventricle; trigeminal ganglion; and ventral grey horn. Orthologous to human UBE2D4 (ubiquitin conjugating enzyme E2 D4 (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 7.3) See more
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Genomic context

Location:: X; X E1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (113817279..113818207)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (114907582..114908510)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

Homologs of the Ube2dnl2 gene: The Ube2dnl2 gene is conserved in rat, zebrafish, A.thaliana, and rice.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 D4

NP_001075130.1

EC 6.3.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081661.1 → NP_001075130.1 ubiquitin-conjugating enzyme E2 D4

See identical proteins and their annotated locations for NP_001075130.1

Status: VALIDATED

Source sequence(s)

AL672098

Consensus CDS

CCDS53176.1

UniProtKB/TrEMBL

A2AFH2

Related

ENSMUSP00000059077.2, ENSMUST00000062695.2

Conserved Domains (2) summary

COG5078
Location:9 → 155

COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]

cl00154
Location:9 → 154

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...