U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Kif27 kinesin family member 27 [ Mus musculus (house mouse) ]

Gene ID: 75050, updated on 18-Apr-2024

Summary

Official Symbol
Kif27provided by MGI
Official Full Name
kinesin family member 27provided by MGI
Primary source
MGI:MGI:1922300
See related
Ensembl:ENSMUSG00000060176 AllianceGenome:MGI:1922300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930517I18Rik
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in cilium assembly. Acts upstream of or within epithelial cilium movement involved in extracellular fluid movement and ventricular system development. Located in cilium. Is expressed in several structures, including choroid plexus; floor plate; genitourinary system; liver; and spleen. Used to study hydrocephalus. Orthologous to human KIF27 (kinesin family member 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 15.0) and CNS E18 (RPKM 0.7) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
13 B1; 13 30.99 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (58432541..58512559, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (58284727..58364745, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34674 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene G kinase anchoring protein 1 Neighboring gene STARR-seq mESC enhancer starr_34675 Neighboring gene predicted gene, 26555 Neighboring gene STARR-seq mESC enhancer starr_34676 Neighboring gene STARR-seq mESC enhancer starr_34677 Neighboring gene STARR-seq mESC enhancer starr_34678 Neighboring gene microRNA 6369 Neighboring gene STARR-seq mESC enhancer starr_34680 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:58474531-58474732 Neighboring gene Q-nucleotide N-glycosylase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein K Neighboring gene microRNA 7-1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
kinesin-like protein KIF27
Names
kinesin-related protein KIF27

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360894.1NP_001347823.1  kinesin-like protein KIF27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154437, AC163038, AW494673, BC116646
    Conserved Domains (1) summary
    COG1196
    Location:258633
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  2. NM_175214.4NP_780423.2  kinesin-like protein KIF27 isoform 1

    See identical proteins and their annotated locations for NP_780423.2

    Status: VALIDATED

    Source sequence(s)
    AC154437, AC163038, AW494673, BK001056
    Consensus CDS
    CCDS26570.1
    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Related
    ENSMUSP00000043304.6, ENSMUST00000043605.6
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    58432541..58512559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517436.4XP_006517499.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517499.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  2. XM_006517433.5XP_006517496.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517496.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  3. XM_011244580.4XP_011242882.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_011242882.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  4. XM_006517435.4XP_006517498.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517498.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  5. XM_036158200.1XP_036014093.1  kinesin-like protein KIF27 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:258633
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  6. XM_006517429.4XP_006517492.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517492.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  7. XM_011244579.3XP_011242881.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_011242881.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  8. XM_017315620.2XP_017171109.1  kinesin-like protein KIF27 isoform X1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  9. XM_017315619.2XP_017171108.1  kinesin-like protein KIF27 isoform X1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  10. XM_006517431.3XP_006517494.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517494.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  11. XM_030247439.1XP_030103299.1  kinesin-like protein KIF27 isoform X5

    Conserved Domains (1) summary
    COG1196
    Location:258633
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  12. XM_006517426.3XP_006517489.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517489.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Related
    ENSMUSP00000153598.2, ENSMUST00000225388.2
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  13. XM_006517427.3XP_006517490.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517490.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  14. XM_006517434.3XP_006517497.1  kinesin-like protein KIF27 isoform X1

    See identical proteins and their annotated locations for XP_006517497.1

    UniProtKB/Swiss-Prot
    Q14AX5, Q7M6Z4, Q8BMB9
    Conserved Domains (2) summary
    COG1196
    Location:7211096
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  15. XM_017315623.1XP_017171112.1  kinesin-like protein KIF27 isoform X4

    Conserved Domains (2) summary
    COG1196
    Location:6731048
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  16. XM_017315621.2XP_017171110.1  kinesin-like protein KIF27 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:7211077
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
  17. XM_017315622.2XP_017171111.1  kinesin-like protein KIF27 isoform X3

    Conserved Domains (3) summary
    TIGR00618
    Location:332967
    sbcc; exonuclease SbcC
    COG0419
    Location:6781203
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd01372
    Location:4342
    KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

RNA

  1. XR_003950487.1 RNA Sequence

  2. XR_001780822.1 RNA Sequence