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Mindy1 MINDY lysine 48 deubiquitinase 1 [ Mus musculus (house mouse) ]

Gene ID: 75007, updated on 8-Nov-2022

Summary

Official Symbol
Mindy1provided by MGI
Official Full Name
MINDY lysine 48 deubiquitinase 1provided by MGI
Primary source
MGI:MGI:1922257
See related
Ensembl:ENSMUSG00000038712 AllianceGenome:MGI:1922257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ni; cI-40; Fam63a; mKIAA1390; 1810005H09Rik; 4930504E06Rik
Summary
Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity; Lys48-specific deubiquitinase activity; and cysteine-type carboxypeptidase activity. Predicted to be involved in protein K48-linked deubiquitination. Predicted to act upstream of or within proteolysis. Predicted to be located in nuclear body. Orthologous to human MINDY1 (MINDY lysine 48 deubiquitinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 42.0), ovary adult (RPKM 32.3) and 28 other tissues See more
Orthologs
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Genomic context

See Mindy1 in Genome Data Viewer
Location:
3; 3 F2.1
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95189237..95203477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95281926..95296166)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene prune exopolyphosphatase Neighboring gene annexin A9 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene predicted gene, 37500

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase MINDY-1
Names
NF-E2 inducible protein
deubiquitinating enzyme MINDY-1
family with sequence similarity 63, member A
protein FAM63A
NP_598619.2
NP_955769.1
XP_006502282.1
XP_011238563.1
XP_030108719.1
XP_030108720.1
XP_036019260.1
XP_036019261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133858.4NP_598619.2  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 2

    See identical proteins and their annotated locations for NP_598619.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
    Source sequence(s)
    AK036838, BC094388, BQ571591
    Consensus CDS
    CCDS17611.1
    UniProtKB/Swiss-Prot
    Q76LS9
    Related
    ENSMUSP00000043910.8, ENSMUST00000039537.14
    Conserved Domains (1) summary
    pfam04424
    Location:144261
    DUF544; Protein of unknown function (DUF544)
  2. NM_199475.1NP_955769.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform 1

    See identical proteins and their annotated locations for NP_955769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC094388, BC132301, BQ571591
    Consensus CDS
    CCDS57233.1
    UniProtKB/Swiss-Prot
    Q76LS9, Q8CHR2
    UniProtKB/TrEMBL
    B7ZMR0
    Related
    ENSMUSP00000102805.3, ENSMUST00000107187.9
    Conserved Domains (1) summary
    pfam04424
    Location:144261
    MINDY_DUB; MINDY deubiquitinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    95189237..95203477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502219.4XP_006502282.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

    See identical proteins and their annotated locations for XP_006502282.1

    UniProtKB/Swiss-Prot
    Q76LS9, Q8CHR2
    UniProtKB/TrEMBL
    B7ZMR0
    Conserved Domains (1) summary
    pfam04424
    Location:144261
    MINDY_DUB; MINDY deubiquitinase
  2. XM_036163368.1XP_036019261.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

    Conserved Domains (1) summary
    pfam04424
    Location:164
    MINDY_DUB; MINDY deubiquitinase
  3. XM_036163367.1XP_036019260.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CHR2
    UniProtKB/TrEMBL
    B7ZMR0
    Conserved Domains (1) summary
    pfam04424
    Location:144261
    MINDY_DUB; MINDY deubiquitinase
  4. XM_030252859.2XP_030108719.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

    Conserved Domains (1) summary
    pfam04424
    Location:164
    MINDY_DUB; MINDY deubiquitinase
  5. XM_011240261.3XP_011238563.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X2

    See identical proteins and their annotated locations for XP_011238563.1

    Conserved Domains (1) summary
    pfam04424
    Location:164
    MINDY_DUB; MINDY deubiquitinase
  6. XM_030252860.1XP_030108720.1  ubiquitin carboxyl-terminal hydrolase MINDY-1 isoform X3

    Conserved Domains (1) summary
    pfam04424
    Location:164
    MINDY_DUB; MINDY deubiquitinase