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Manf mesencephalic astrocyte-derived neurotrophic factor [ Mus musculus (house mouse) ]

Gene ID: 74840, updated on 19-Mar-2023


Official Symbol
Manfprovided by MGI
Official Full Name
mesencephalic astrocyte-derived neurotrophic factorprovided by MGI
Primary source
See related
Ensembl:ENSMUSG00000032575 AllianceGenome:MGI:1922090
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Armet; D18Mgi17; 3230402M22Rik
Predicted to enable sulfatide binding activity. Acts upstream of or within vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure. Predicted to be located in endoplasmic reticulum lumen and perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in Parkinsonism; breast cancer; carcinoma (multiple); and pancreatic cancer. Orthologous to human MANF (mesencephalic astrocyte derived neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in placenta adult (RPKM 52.6), testis adult (RPKM 26.4) and 26 other tissues See more
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Genomic context

See Manf in Genome Data Viewer
9 F1; 9 57.98 cM
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106765952..106769137, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106888753..106891938, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAD54 like 2 (S. cerevisiae) Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene RNA binding motif protein 15B Neighboring gene dedicator of cyto-kinesis 3 Neighboring gene predicted gene, 18542 Neighboring gene pleckstrin homology domain-containing, family A (phosphoinositide binding specific) member 3 pseudogene

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
enables lipid binding IEA
Inferred from Electronic Annotation
more info
enables sulfatide binding ISO
Inferred from Sequence Orthology
more info
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
mesencephalic astrocyte-derived neurotrophic factor
arginine-rich protein
arginine-rich, mutated in early stage tumors

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029103.4NP_083379.2  mesencephalic astrocyte-derived neurotrophic factor precursor

    See identical proteins and their annotated locations for NP_083379.2

    Status: VALIDATED

    Source sequence(s)
    Consensus CDS
    A0A6P5QIG3, A0A8C6GUY6, Q3TMX5
    ENSMUSP00000124562.2, ENSMUST00000159283.8
    Conserved Domains (1) summary
    Armet; Degradation arginine-rich protein for mis-folding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000075.7 Reference GRCm39 C57BL/6J

    106765952..106769137 complement
    GenBank, FASTA, Sequence Viewer (Graphics)