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WNT9B Wnt family member 9B [ Homo sapiens (human) ]

Gene ID: 7484, updated on 21-Dec-2019

Summary

Official Symbol
WNT9Bprovided by HGNC
Official Full Name
Wnt family member 9Bprovided by HGNC
Primary source
HGNC:HGNC:12779
See related
Ensembl:ENSG00000158955 MIM:602864
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WNT15; WNT14B
Summary
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Biased expression in kidney (RPKM 1.6), skin (RPKM 0.7) and 9 other tissues See more
Orthologs

Genomic context

See WNT9B in Genome Data Viewer
Location:
17q21.32
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (46833201..46886738)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44928952..44964096)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene ZFP161 motif-containing MPRA enhancer 249 Neighboring gene Wnt family member 3 Neighboring gene uncharacterized LOC101929777 Neighboring gene uncharacterized LOC112268191 Neighboring gene long intergenic non-protein coding RNA 1974

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IEA
Inferred from Electronic Annotation
more info
 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway IEA
Inferred from Electronic Annotation
more info
 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
collecting duct development IEA
Inferred from Electronic Annotation
more info
 
cornea development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
embryonic cranial skeleton morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment of planar polarity involved in nephron morphogenesis IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
kidney rudiment formation IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal stem cell maintenance involved in nephron morphogenesis IEA
Inferred from Electronic Annotation
more info
 
mesonephric duct formation IEA
Inferred from Electronic Annotation
more info
 
metanephric tubule formation IEA
Inferred from Electronic Annotation
more info
 
midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of asymmetric cell division IEA
Inferred from Electronic Annotation
more info
 
regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of tube size IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid NAS
Non-traceable Author Statement
more info
PubMed 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
uterus morphogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Wnt-9b
Names
protein Wnt-14b
wingless-type MMTV integration site family member 9B
wingless-type MMTV integration site family, member 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029164.3 RefSeqGene

    Range
    4982..33959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320458.2NP_001307387.1  protein Wnt-9b isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate penultimate exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2 which has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC015855
    Consensus CDS
    CCDS82147.1
    UniProtKB/TrEMBL
    E7EPC3
    Related
    ENSP00000377105.2, ENST00000393461.2
    Conserved Domains (1) summary
    pfam00110
    Location:60302
    wnt; wnt family
  2. NM_003396.3NP_003387.1  protein Wnt-9b isoform 1 precursor

    See identical proteins and their annotated locations for NP_003387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC015855
    Consensus CDS
    CCDS11506.1
    UniProtKB/Swiss-Prot
    O14905
    Related
    ENSP00000290015.2, ENST00000290015.7
    Conserved Domains (1) summary
    pfam00110
    Location:60356
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    46833201..46886738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525178.2XP_011523480.1  protein Wnt-9b isoform X1

    See identical proteins and their annotated locations for XP_011523480.1

    Conserved Domains (1) summary
    pfam00110
    Location:66362
    wnt; wnt family

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1370998..1406155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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