U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Naa15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit [ Mus musculus (house mouse) ]

Gene ID: 74838, updated on 5-Mar-2024

Summary

Official Symbol
Naa15provided by MGI
Official Full Name
N(alpha)-acetyltransferase 15, NatA auxiliary subunitprovided by MGI
Primary source
MGI:MGI:1922088
See related
Ensembl:ENSMUSG00000063273 AllianceGenome:MGI:1922088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Narg1; mNAT1; ASTBDN; Tbdn-1; 6330400I15; 5730450D16Rik
Summary
Enables N-acetyltransferase activity. Predicted to be involved in several processes, including N-terminal peptidyl-methionine acetylation; positive regulation of transcription, DNA-templated; and protein stabilization. Predicted to act upstream of or within angiogenesis and cell differentiation. Located in cytoplasm. Is expressed in several structures, including brain; cornea endothelium; genitourinary system; gut; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 50. Orthologous to human NAA15 (N-alpha-acetyltransferase 15, NatA auxiliary subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 15.4), placenta adult (RPKM 10.3) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Naa15 in Genome Data Viewer
Location:
3 C; 3 22.47 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (51323437..51383406)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (51416016..51475985)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07614 Neighboring gene predicted gene 9442 Neighboring gene NADH:ubiquinone oxidoreductase subunit C1 Neighboring gene STARR-positive B cell enhancer ABC_E11182 Neighboring gene predicted gene, 50622 Neighboring gene STARR-positive B cell enhancer ABC_E2664 Neighboring gene RAB33B, member RAS oncogene family Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:51314972-51315081 Neighboring gene predicted gene, 36008

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC29428

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
 
contributes_to ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in N-terminal protein amino acid acetylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NatA complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
N-alpha-acetyltransferase 15, NatA auxiliary subunit
Names
N-terminal acetyltransferase 1
N-terminal aceyltransferase 1
NMDA receptor-regulated gene 1
NMDA receptor-regulated protein 1
protein tubedown-1
tubedown

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053089.3NP_444319.3  N-alpha-acetyltransferase 15, NatA auxiliary subunit

    See identical proteins and their annotated locations for NP_444319.3

    Status: VALIDATED

    Source sequence(s)
    AB221683, AC102860, BQ887090, CA327064, CX241349
    Consensus CDS
    CCDS17340.1
    UniProtKB/Swiss-Prot
    Q80UM3, Q811Z9, Q9JID5
    UniProtKB/TrEMBL
    G3X8Y3
    Related
    ENSMUSP00000029303.8, ENSMUST00000029303.13
    Conserved Domains (3) summary
    sd00006
    Location:82108
    TPR; TPR repeat [structural motif]
    pfam12569
    Location:187698
    NARP1; NMDA receptor-regulated protein 1
    pfam13414
    Location:82145
    TPR_11; TPR repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    51323437..51383406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)