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WNT9A Wnt family member 9A [ Homo sapiens (human) ]

Gene ID: 7483, updated on 3-May-2020

Summary

Official Symbol
WNT9Aprovided by HGNC
Official Full Name
Wnt family member 9Aprovided by HGNC
Primary source
HGNC:HGNC:12778
See related
Ensembl:ENSG00000143816 MIM:602863
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WNT14
Summary
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 3.6), endometrium (RPKM 2.9) and 21 other tissues See more
Orthologs

Genomic context

See WNT9A in Genome Data Viewer
Location:
1q42.13
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (227918656..227947932, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228109165..228135676, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LOC105373289 Neighboring gene serine protease 38 Neighboring gene microRNA 5008 Neighboring gene uncharacterized LOC107985355 Neighboring gene putative uncharacterized protein FLJ44672

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC138165, MGC141991

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell signaling NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cornea development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal joint development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic skeletal system morphogenesis IEA
Inferred from Electronic Annotation
more info
 
iris morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chondrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Wnt-9a
Names
wingless-type MMTV integration site family, member 14
wingless-type MMTV integration site family, member 9A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003395.4NP_003386.1  protein Wnt-9a precursor

    See identical proteins and their annotated locations for NP_003386.1

    Status: VALIDATED

    Source sequence(s)
    AB060283, AI280246, AK131041, AL360269
    Consensus CDS
    CCDS31045.1
    UniProtKB/Swiss-Prot
    O14904
    UniProtKB/TrEMBL
    D9ZGG3
    Related
    ENSP00000272164.5, ENST00000272164.6
    Conserved Domains (1) summary
    pfam00110
    Location:64364
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    227918656..227947932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544271.2XP_011542573.1  protein Wnt-9a isoform X1

    Conserved Domains (1) summary
    pfam00110
    Location:1294
    wnt; wnt family
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