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WNT10B Wnt family member 10B [ Homo sapiens (human) ]

Gene ID: 7480, updated on 1-Jun-2020

Summary

Official Symbol
WNT10Bprovided by HGNC
Official Full Name
Wnt family member 10Bprovided by HGNC
Primary source
HGNC:HGNC:12775
See related
Ensembl:ENSG00000169884 MIM:601906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHFM6; STHAG8; WNT-12
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 3.0), skin (RPKM 0.8) and 15 other tissues See more
Orthologs

Genomic context

See WNT10B in Genome Data Viewer
Location:
12q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48965340..48979587, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (49359123..49365641, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 11 Neighboring gene ADP ribosylation factor 3 Neighboring gene RNA, U6 small nuclear 940, pseudogene Neighboring gene uncharacterized LOC105369757 Neighboring gene Wnt family member 1 Neighboring gene uncharacterized LOC105369756

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor ligand activity IC
Inferred by Curator
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
cellular response to parathyroid hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
chondrocyte differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
fungiform papilla development IEA
Inferred from Electronic Annotation
more info
 
hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
myoblast differentiation involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of timing of anagen IEA
Inferred from Electronic Annotation
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
sensory perception of taste IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein Wnt-10b
Names
WNT-10B protein
wingless-type MMTV integration site family, member 10B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023347.1 RefSeqGene

    Range
    5124..11519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003394.4NP_003385.2  protein Wnt-10b precursor

    See identical proteins and their annotated locations for NP_003385.2

    Status: REVIEWED

    Source sequence(s)
    BC096356, DA530656, U81787
    Consensus CDS
    CCDS8775.1
    UniProtKB/Swiss-Prot
    O00744
    Related
    ENSP00000301061.4, ENST00000301061.9
    Conserved Domains (1) summary
    pfam00110
    Location:50389
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48965340..48979587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449179.1XP_024304947.1  protein Wnt-10b isoform X1

    Conserved Domains (1) summary
    pfam00110
    Location:3267
    wnt; wnt family
  2. XM_011538722.1XP_011537024.1  protein Wnt-10b isoform X1

    See identical proteins and their annotated locations for XP_011537024.1

    Conserved Domains (1) summary
    pfam00110
    Location:3267
    wnt; wnt family
  3. XM_017019919.1XP_016875408.1  protein Wnt-10b isoform X1

    Conserved Domains (1) summary
    pfam00110
    Location:3267
    wnt; wnt family
  4. XM_011538724.1XP_011537026.1  protein Wnt-10b isoform X2

    Related
    ENSP00000385980.1, ENST00000403957.5
    Conserved Domains (1) summary
    cl19568
    Location:54141
    wnt; wnt family
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