Format

Send to:

Choose Destination

WNT8B Wnt family member 8B [ Homo sapiens (human) ]

Gene ID: 7479, updated on 2-Mar-2021

Summary

Official Symbol
WNT8Bprovided by HGNC
Official Full Name
Wnt family member 8Bprovided by HGNC
Primary source
HGNC:HGNC:12789
See related
Ensembl:ENSG00000075290 MIM:601396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See WNT8B in Genome Data Viewer
Location:
10q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (100463009..100483744)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102222766..102243501)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene stearoyl-CoA desaturase Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene uncharacterized LOC105378452 Neighboring gene VISTA enhancer hs1006 Neighboring gene SEC31 homolog B, COPII coat complex component

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
determination of dorsal identity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to estradiol NAS
Non-traceable Author Statement
more info
PubMed 
response to retinoic acid NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Wnt-8b
Names
epididymis secretory sperm binding protein
wingless-type MMTV integration site family, member 8B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003393.4NP_003384.2  protein Wnt-8b precursor

    See identical proteins and their annotated locations for NP_003384.2

    Status: REVIEWED

    Source sequence(s)
    AB073637, AL133352, AL359759, CN276452
    Consensus CDS
    CCDS7494.1
    UniProtKB/Swiss-Prot
    Q93098
    Related
    ENSP00000340677.5, ENST00000343737.6
    Conserved Domains (1) summary
    smart00097
    Location:23333
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    100463009..100483744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center