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WNT8B Wnt family member 8B [ Homo sapiens (human) ]

Gene ID: 7479, updated on 27-Nov-2024

Summary

Official Symbol
WNT8Bprovided by HGNC
Official Full Name
Wnt family member 8Bprovided by HGNC
Primary source
HGNC:HGNC:12789
See related
Ensembl:ENSG00000075290 MIM:601396; AllianceGenome:HGNC:12789
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See WNT8B in Genome Data Viewer
Location:
10q24.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (100463009..100483744)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (101346091..101366850)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102222766..102243501)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:102106425-102107016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102114334-102114834 Neighboring gene stearoyl-CoA desaturase Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102132955-102133524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102133525-102134092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102134093-102134662 Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102214151-102214652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102242041-102242696 Neighboring gene VISTA enhancer hs1006 Neighboring gene SEC31 homolog B, COPII coat complex component Neighboring gene MPRA-validated peak1070 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:102289335-102289917 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in determination of dorsal identity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to estradiol NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to retinoic acid NAS
Non-traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein Wnt-8b
Names
epididymis secretory sperm binding protein
wingless-type MMTV integration site family, member 8B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003393.4NP_003384.2  protein Wnt-8b precursor

    See identical proteins and their annotated locations for NP_003384.2

    Status: REVIEWED

    Source sequence(s)
    AB073637, AL133352, AL359759, CN276452
    Consensus CDS
    CCDS7494.1
    UniProtKB/Swiss-Prot
    O00771, Q5VX55, Q8WYK9, Q93098
    UniProtKB/TrEMBL
    A0A384NKY7
    Related
    ENSP00000340677.5, ENST00000343737.6
    Conserved Domains (1) summary
    smart00097
    Location:23333
    WNT1; found in Wnt-1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    100463009..100483744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    101346091..101366850
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)