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WNT8A Wnt family member 8A [ Homo sapiens (human) ]

Gene ID: 7478, updated on 2-Mar-2021

Summary

Official Symbol
WNT8Aprovided by HGNC
Official Full Name
Wnt family member 8Aprovided by HGNC
Primary source
HGNC:HGNC:12788
See related
Ensembl:ENSG00000061492 MIM:606360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WNT8D
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See WNT8A in Genome Data Viewer
Location:
5q31.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (138077367..138092900)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (137419722..137428054)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 13 member B Neighboring gene uncharacterized LOC100130172 Neighboring gene RNA, U6 small nuclear 1148, pseudogene Neighboring gene RNA, U6 small nuclear 460, pseudogene Neighboring gene RNA, U6 small nuclear 888, pseudogene Neighboring gene NME/NM23 family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding NAS
Non-traceable Author Statement
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor ligand activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
anterior/posterior axis specification ISS
Inferred from Sequence or Structural Similarity
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IEP
Inferred from Expression Pattern
more info
PubMed 
canonical Wnt signaling pathway involved in neural crest cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural crest cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
response to retinoic acid NAS
Non-traceable Author Statement
more info
PubMed 
secondary palate development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein Wnt-8a
Names
WNT8d
protein Wnt-8d
wingless-type MMTV integration site family, member 8A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300938.2NP_001287867.1  protein Wnt-8a isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB057725, AY009402, BC144001
    UniProtKB/Swiss-Prot
    Q9H1J5
    Related
    ENSP00000424809.1, ENST00000504809.5
    Conserved Domains (1) summary
    smart00097
    Location:41349
    WNT1; found in Wnt-1
  2. NM_001300939.2NP_001287868.1  protein Wnt-8a isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 3' region, which results in an alternate translation stop codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB057725, AY009402, BC144497
    Consensus CDS
    CCDS75311.1
    UniProtKB/Swiss-Prot
    Q9H1J5
    UniProtKB/TrEMBL
    D6RF47
    Related
    ENSP00000426653.1, ENST00000506684.6
    Conserved Domains (1) summary
    smart00097
    Location:41354
    WNT1; found in Wnt-1
  3. NM_058244.4NP_490645.1  protein Wnt-8a isoform 3 precursor

    See identical proteins and their annotated locations for NP_490645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal segment in the 5' region and has an additional segment in the 3' region, which result in alternate translation start codon and stop codon respectively, compared to variant 1. The resulting isoform (3) is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AB057725, AY009402, BC144497
    Consensus CDS
    CCDS43368.1
    UniProtKB/Swiss-Prot
    Q9H1J5
    Related
    ENSP00000381739.1, ENST00000398754.1
    Conserved Domains (1) summary
    smart00097
    Location:21336
    WNT1; found in Wnt-1

RNA

  1. NR_125351.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal segment in the 5' region and has an alternate splice junction in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translation start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY009402, BC144497
    Related
    ENST00000361560.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    138077367..138092900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009826.1XP_016865315.1  protein Wnt-8a isoform X4

  2. XM_017009825.1XP_016865314.1  protein Wnt-8a isoform X2

  3. XM_017009824.1XP_016865313.1  protein Wnt-8a isoform X1

  4. XM_011543625.2XP_011541927.2  protein Wnt-8a isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031933.1: Suppressed sequence

    Description
    NM_031933.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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