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WNT7B Wnt family member 7B [ Homo sapiens (human) ]

Gene ID: 7477, updated on 7-Jun-2020

Summary

Official Symbol
WNT7Bprovided by HGNC
Official Full Name
Wnt family member 7Bprovided by HGNC
Primary source
HGNC:HGNC:12787
See related
Ensembl:ENSG00000188064 MIM:601967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
Expression
Biased expression in skin (RPKM 7.3), urinary bladder (RPKM 3.8) and 6 other tissues See more
Orthologs

Genomic context

See WNT7B in Genome Data Viewer
Location:
22q13.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (45920362..45977162, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46316246..46373008, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985535 Neighboring gene uncharacterized LOC105373071 Neighboring gene Sharpr-MPRA regulatory region 1865 Neighboring gene dynein heavy chain -like pseudogene Neighboring gene long intergenic non-protein coding RNA 899

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to retinoic acid IEP
Inferred from Expression Pattern
more info
PubMed 
central nervous system vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
chorio-allantoic fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
developmental growth involved in morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic placenta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment or maintenance of polarity of embryonic epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
fibroblast proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
forebrain regionalization IEP
Inferred from Expression Pattern
more info
PubMed 
homeostatic process ISS
Inferred from Sequence or Structural Similarity
more info
 
in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
inner medullary collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
lens fiber cell development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
lobar bronchus development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
lung morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
metanephric collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric epithelium development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephric loop of Henle development ISS
Inferred from Sequence or Structural Similarity
more info
 
metanephros morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outer medullary collecting duct development ISS
Inferred from Sequence or Structural Similarity
more info
 
oxygen homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JNK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell projection size IEA
Inferred from Electronic Annotation
more info
 
renal inner medulla development ISS
Inferred from Sequence or Structural Similarity
more info
 
renal outer medulla development ISS
Inferred from Sequence or Structural Similarity
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
stem cell proliferation IEP
Inferred from Expression Pattern
more info
PubMed 
synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
trachea cartilage morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein Wnt-7b
Names
wingless-type MMTV integration site family, member 7B

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058238.3NP_478679.1  protein Wnt-7b precursor

    See identical proteins and their annotated locations for NP_478679.1

    Status: REVIEWED

    Source sequence(s)
    AB062766, AF416743, BX511035, CB853639, CR536603
    Consensus CDS
    CCDS33667.1
    UniProtKB/Swiss-Prot
    P56706
    Related
    ENSP00000341032.4, ENST00000339464.9
    Conserved Domains (1) summary
    pfam00110
    Location:40349
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    45920362..45977162 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530366.1XP_011528668.1  protein Wnt-7b isoform X1

    See identical proteins and their annotated locations for XP_011528668.1

    UniProtKB/TrEMBL
    A8K0G1
    Related
    ENSP00000386546.3, ENST00000409496.7
    Conserved Domains (1) summary
    pfam00110
    Location:44353
    wnt; wnt family
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