Trmo tRNA methyltransferase O [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trmoprovided by MGI
Official Full Name: tRNA methyltransferase Oprovided by MGI
Primary source: MGI:MGI:1922003
See related: Ensembl:ENSMUSG00000028331 AllianceGenome:MGI:1922003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nap1; 5830415F09Rik
Summary: Predicted to enable tRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Orthologous to human TRMO (tRNA methyltransferase O). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E14.5 (RPKM 6.3), liver E14 (RPKM 5.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 B1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (46376505..46393557, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (46376504..46393557, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Trmo gene: The Trmo gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 363 organisms have orthologs with human gene Trmo
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA m6t6A37 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in tRNA methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: tRNA (adenine(37)-N6)-methyltransferase

Names: likely ortholog of H. sapiens chromosome 9 open reading frame 156 (C9orf156); nef-associated protein 1; thioesterase NAP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347095.1 → NP_001334024.1 tRNA (adenine(37)-N6)-methyltransferase isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL806523

Consensus CDS

CCDS84727.1

UniProtKB/Swiss-Prot

Q562D6, Q9D3F5

Related

ENSMUSP00000030015.6, ENSMUST00000030015.6
NM_029086.2 → NP_083362.1 tRNA (adenine(37)-N6)-methyltransferase isoform 1

See identical proteins and their annotated locations for NP_083362.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK153576

Consensus CDS

CCDS18148.1

UniProtKB/Swiss-Prot

Q562D6

Related

ENSMUSP00000083752.5, ENSMUST00000086563.11

Conserved Domains (1) summary

cd09281
Location:32 → 159

UPF0066; Escherichia coli YaeB and related proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

46376505..46393557 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320423.2 → XP_017175912.1 tRNA (adenine(37)-N6)-methyltransferase isoform X2

Conserved Domains (2) summary

pfam18389
Location:251 → 313

TrmO_C; TrmO C-terminal domain

pfam01980
Location:2 → 90

UPF0066; Uncharacterized protein family UPF0066
XM_017320422.1 → XP_017175911.1 tRNA (adenine(37)-N6)-methyltransferase isoform X1

Conserved Domains (2) summary

pfam18389
Location:328 → 390

TrmO_C; TrmO C-terminal domain

pfam01980
Location:48 → 167

UPF0066; Uncharacterized protein family UPF0066