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Trmo tRNA methyltransferase O [ Mus musculus (house mouse) ]

Gene ID: 74753, updated on 12-May-2024

Summary

Official Symbol
Trmoprovided by MGI
Official Full Name
tRNA methyltransferase Oprovided by MGI
Primary source
MGI:MGI:1922003
See related
Ensembl:ENSMUSG00000028331 AllianceGenome:MGI:1922003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nap1; 5830415F09Rik
Summary
Predicted to enable tRNA (adenine-N6-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to act upstream of or within methylation and tRNA processing. Orthologous to human TRMO (tRNA methyltransferase O). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14.5 (RPKM 6.3), liver E14 (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See Trmo in Genome Data Viewer
Location:
4 B1; 4 24.71 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46376505..46393557, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46376504..46393557, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12446 Neighboring gene predicted gene 12447 Neighboring gene forkhead box E1 Neighboring gene STARR-seq mESC enhancer starr_10125 Neighboring gene hemogen Neighboring gene acidic nuclear phosphoprotein 32 family member B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA (L-threonylcarbamoyladenosine(37)-C2) methyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
tRNA (adenine(37)-N6)-methyltransferase
Names
likely ortholog of H. sapiens chromosome 9 open reading frame 156 (C9orf156)
nef-associated protein 1
thioesterase NAP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347095.1NP_001334024.1  tRNA (adenine(37)-N6)-methyltransferase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL806523
    Consensus CDS
    CCDS84727.1
    UniProtKB/Swiss-Prot
    Q3U5H3, Q562D6, Q8BRJ8, Q9D3F5
    UniProtKB/TrEMBL
    F6QNL9
    Related
    ENSMUSP00000030015.6, ENSMUST00000030015.6
  2. NM_029086.2NP_083362.1  tRNA (adenine(37)-N6)-methyltransferase isoform 1

    See identical proteins and their annotated locations for NP_083362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK153576
    Consensus CDS
    CCDS18148.1
    UniProtKB/TrEMBL
    F6QNL9
    Related
    ENSMUSP00000083752.5, ENSMUST00000086563.11
    Conserved Domains (1) summary
    cd09281
    Location:32159
    UPF0066; Escherichia coli YaeB and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46376505..46393557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320423.2XP_017175912.1  tRNA (adenine(37)-N6)-methyltransferase isoform X2

    UniProtKB/TrEMBL
    F6QNL9
    Conserved Domains (2) summary
    pfam18389
    Location:251313
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:290
    UPF0066; Uncharacterized protein family UPF0066
  2. XM_017320422.1XP_017175911.1  tRNA (adenine(37)-N6)-methyltransferase isoform X1

    UniProtKB/TrEMBL
    F6QNL9
    Conserved Domains (2) summary
    pfam18389
    Location:328390
    TrmO_C; TrmO C-terminal domain
    pfam01980
    Location:48167
    UPF0066; Uncharacterized protein family UPF0066

RNA

  1. XR_390347.2 RNA Sequence