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WNT6 Wnt family member 6 [ Homo sapiens (human) ]

Gene ID: 7475, updated on 13-May-2022

Summary

Official Symbol
WNT6provided by HGNC
Official Full Name
Wnt family member 6provided by HGNC
Primary source
HGNC:HGNC:12785
See related
Ensembl:ENSG00000115596 MIM:604663; AllianceGenome:HGNC:12785
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
Expression
Biased expression in placenta (RPKM 1.4), prostate (RPKM 1.1) and 13 other tissues See more
Orthologs
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Genomic context

See WNT6 in Genome Data Viewer
Location:
2q35
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (218859805..218874233)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (219348208..219362636)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219724528..219738955)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 9500 Neighboring gene protein kinase AMP-activated non-catalytic subunit gamma 3 Neighboring gene ribosomal protein L23a pseudogene 31 Neighboring gene Wnt family member 10A Neighboring gene uncharacterized LOC105373882 Neighboring gene Sharpr-MPRA regulatory region 8081 Neighboring gene long intergenic non-protein coding RNA 1494 Neighboring gene uncharacterized LOC124906119 Neighboring gene RNA, U6 small nuclear 642, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cornea development in camera-type eye ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in epithelial-mesenchymal cell signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in nephron tubule formation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tooth mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular exosome TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein Wnt-6
Names
wingless-type MMTV integration site family, member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046932.1 RefSeqGene

    Range
    4983..19411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006522.4NP_006513.1  protein Wnt-6 precursor

    See identical proteins and their annotated locations for NP_006513.1

    Status: REVIEWED

    Source sequence(s)
    AB059570, AC009974, AC073128, AK075522, BC004329, CB960823
    Consensus CDS
    CCDS2425.1
    UniProtKB/Swiss-Prot
    Q9Y6F9
    UniProtKB/TrEMBL
    Q8N2E5
    Related
    ENSP00000233948.3, ENST00000233948.4
    Conserved Domains (1) summary
    pfam00110
    Location:47364
    wnt; wnt family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    218859805..218874233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    219348208..219362636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)