Trim14 tripartite motif-containing 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim14provided by MGI
Official Full Name: tripartite motif-containing 14provided by MGI
Primary source: MGI:MGI:1921985
See related: Ensembl:ENSMUSG00000039853 AllianceGenome:MGI:1921985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: pub; 5830400N10Rik
Summary: Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of viral transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of NF-kappaB transcription factor activity. Predicted to act upstream of or within immune system process. Predicted to be located in cytoplasmic vesicle and mitochondrial outer membrane. Predicted to be active in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human TRIM14 (tripartite motif containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 8.5), small intestine adult (RPKM 7.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 B1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (46505072..46536148, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (46505072..46536150, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trim14 promotes osteoclastogenesis and noncanonical NF-kappaB activation by targeting p100/p52 in chronic periodontitis.
Title: Trim14 promotes osteoclastogenesis and noncanonical NF-κB activation by targeting p100/p52 in chronic periodontitis.
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
Title: TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation.
TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.
Title: TRIM14 Is a Key Regulator of the Type I IFN Response during Mycobacterium tuberculosis Infection.
study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response
Title: The Ubiquitin Ligase RNF125 Targets Innate Immune Adaptor Protein TRIM14 for Ubiquitination and Degradation.
TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses.
Title: TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses.
These results demonstrate the presence of the similar mechanism of trim14 gene action in different types of mammalian cells.
Title: Trim14 overexpression causes the same transcriptional changes in mouse embryonic stem cells and human HEK293 cells.
Pub gene participates in early stages of differentiation of embryonic stem cells leading to the formation of embryoid bodies.
Title: Different effects of enhanced and reduced expression of pub gene on the formation of embryoid bodies by cultured embryonic mouse stem cell.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI563590 (e-PCR)
- UniSTS:178995

NoName (e-PCR)
- UniSTS:492526

Homology

Homologs of the Trim14 gene: The Trim14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 321 organisms have orthologs with human gene Trim14
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 14

Names: PU.1 binding protein Pub

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029077.4 → NP_083353.1 tripartite motif-containing protein 14

See identical proteins and their annotated locations for NP_083353.1

Status: VALIDATED

Source sequence(s)

AB117644, AK133220, AV326753

Consensus CDS

CCDS18153.1

UniProtKB/Swiss-Prot

Q8BVW3, Q9D3G8

UniProtKB/TrEMBL

Q14AR3, Q3V0E0

Related

ENSMUSP00000038719.7, ENSMUST00000046897.13

Conserved Domains (2) summary

pfam00643
Location:20 → 56

zf-B_box; B-box zinc finger

cd13738
Location:267 → 439

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

46505072..46536148 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164508.1 → XP_036020401.1 tripartite motif-containing protein 14 isoform X1

UniProtKB/TrEMBL

Q3TA17

Conserved Domains (1) summary

cd13738
Location:112 → 284

SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
XM_017320421.3 → XP_017175910.1 tripartite motif-containing protein 14 isoform X2

Conserved Domains (1) summary

cd19768
Location:20 → 63

Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins
XM_017320420.3 → XP_017175909.1 tripartite motif-containing protein 14 isoform X2

Conserved Domains (1) summary

cd19768
Location:20 → 63

Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins