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Trim14 tripartite motif-containing 14 [ Mus musculus (house mouse) ]

Gene ID: 74735, updated on 30-Apr-2024

Summary

Official Symbol
Trim14provided by MGI
Official Full Name
tripartite motif-containing 14provided by MGI
Primary source
MGI:MGI:1921985
See related
Ensembl:ENSMUSG00000039853 AllianceGenome:MGI:1921985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
pub; 5830400N10Rik
Summary
Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of viral transcription; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of NF-kappaB transcription factor activity. Predicted to act upstream of or within immune system process. Predicted to be located in cytoplasmic vesicle and mitochondrial outer membrane. Predicted to be active in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human TRIM14 (tripartite motif containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 8.5), small intestine adult (RPKM 7.5) and 19 other tissues See more
Orthologs
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Genomic context

See Trim14 in Genome Data Viewer
Location:
4 B1; 4 24.84 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46505072..46536148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46505072..46536150, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member B Neighboring gene STARR-positive B cell enhancer ABC_E9585 Neighboring gene STARR-positive B cell enhancer ABC_E3487 Neighboring gene predicted gene, 22247 Neighboring gene N-acetylneuraminic acid synthase (sialic acid synthase) Neighboring gene STARR-positive B cell enhancer ABC_E3488 Neighboring gene predicted gene, 54223 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E4623 Neighboring gene STARR-positive B cell enhancer ABC_E3489 Neighboring gene STARR-positive B cell enhancer ABC_E3490 Neighboring gene predicted gene, 54221 Neighboring gene STARR-positive B cell enhancer ABC_E6173 Neighboring gene predicted gene, 54222 Neighboring gene STARR-positive B cell enhancer ABC_E2111 Neighboring gene TBC1 domain family, member 2 Neighboring gene predicted gene, 31850

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tripartite motif-containing protein 14
Names
PU.1 binding protein Pub

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029077.4NP_083353.1  tripartite motif-containing protein 14

    See identical proteins and their annotated locations for NP_083353.1

    Status: VALIDATED

    Source sequence(s)
    AB117644, AK133220, AV326753
    Consensus CDS
    CCDS18153.1
    UniProtKB/Swiss-Prot
    B1AVH3, Q6A0C3, Q762I6, Q8BVW3, Q9D3G8
    UniProtKB/TrEMBL
    Q14AR3, Q3V0E0
    Related
    ENSMUSP00000038719.7, ENSMUST00000046897.13
    Conserved Domains (2) summary
    pfam00643
    Location:2056
    zf-B_box; B-box zinc finger
    cd13738
    Location:267439
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    46505072..46536148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164508.1XP_036020401.1  tripartite motif-containing protein 14 isoform X1

    UniProtKB/TrEMBL
    Q3TA17
    Conserved Domains (1) summary
    cd13738
    Location:112284
    SPRY_PRY_TRIM14; PRY/SPRY domain of tripartite motif-binding protein 14 (TRIM14)
  2. XM_017320421.3XP_017175910.1  tripartite motif-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    Q3UF89
    Conserved Domains (1) summary
    cd19768
    Location:2063
    Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins
  3. XM_017320420.3XP_017175909.1  tripartite motif-containing protein 14 isoform X2

    UniProtKB/TrEMBL
    Q3UF89
    Conserved Domains (1) summary
    cd19768
    Location:2063
    Bbox2_TRIM14; B-box-type 2 zinc finger found in tripartite motif-containing protein 14 (TRIM14) and similar proteins