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Rhoh ras homolog family member H [ Mus musculus (house mouse) ]

Gene ID: 74734, updated on 8-Dec-2022

Summary

Official Symbol
Rhohprovided by MGI
Official Full Name
ras homolog family member Hprovided by MGI
Primary source
MGI:MGI:1921984
See related
Ensembl:ENSMUSG00000029204 AllianceGenome:MGI:1921984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arhh; 5830400A04Rik
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and kinase inhibitor activity. Involved in T cell differentiation and mast cell activation. Located in cytoplasm and immunological synapse. Is expressed in cranial ganglion; dorsal root ganglion; and sensory organ. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human RHOH (ras homolog family member H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 18.6), spleen adult (RPKM 6.0) and 2 other tissues See more
Orthologs
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Genomic context

See Rhoh in Genome Data Viewer
Location:
5; 5 C3.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66018092..66054043)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65860742..65896700)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene NEDD4 binding protein 2 Neighboring gene predicted gene 5296 Neighboring gene predicted gene 3521 Neighboring gene predicted gene, 32474 Neighboring gene predicted gene, 32556

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mast cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho-related GTP-binding protein RhoH
Names
ras homolog gene family, member H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081105.2NP_001074574.1  rho-related GTP-binding protein RhoH

    See identical proteins and their annotated locations for NP_001074574.1

    Status: VALIDATED

    Source sequence(s)
    AC156029
    Consensus CDS
    CCDS39100.1
    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    A0A8C6GTI6, Q504M6
    Related
    ENSMUSP00000143810.2, ENSMUST00000201533.2
    Conserved Domains (1) summary
    cd00157
    Location:5169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
  2. NM_001363454.1NP_001350383.1  rho-related GTP-binding protein RhoH

    Status: VALIDATED

    Source sequence(s)
    AC156029, AI448508, AK137909, AK138090
    Consensus CDS
    CCDS39100.1
    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    A0A8C6GTI6, Q504M6
    Related
    ENSMUSP00000031106.5, ENSMUST00000031106.8
    Conserved Domains (1) summary
    cd00157
    Location:5169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    66018092..66054043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254861.2XP_030110721.1  rho-related GTP-binding protein RhoH isoform X1

    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    A0A8C6GTI6, Q504M6
    Conserved Domains (1) summary
    cd00157
    Location:5169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)
  2. XM_011240779.4XP_011239081.1  rho-related GTP-binding protein RhoH isoform X1

    See identical proteins and their annotated locations for XP_011239081.1

    UniProtKB/Swiss-Prot
    Q9D3G9
    UniProtKB/TrEMBL
    A0A8C6GTI6, Q504M6
    Conserved Domains (1) summary
    cd00157
    Location:5169
    Rho; Ras homology family (Rho) of small guanosine triphosphatases (GTPases)