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Stx11 syntaxin 11 [ Mus musculus (house mouse) ]

Gene ID: 74732, updated on 27-Feb-2024

Summary

Official Symbol
Stx11provided by MGI
Official Full Name
syntaxin 11provided by MGI
Primary source
MGI:MGI:1921982
See related
Ensembl:ENSMUSG00000039232 AllianceGenome:MGI:1921982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830405C08Rik
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within cellular response to interferon-gamma and leukocyte degranulation. Located in phagocytic vesicle. Is expressed in femur; fibula; humerus; scapula; and tibia. Used to study familial hemophagocytic lymphohistiocytosis 4. Human ortholog(s) of this gene implicated in familial hemophagocytic lymphohistiocytosis 4. Orthologous to human STX11 (syntaxin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 7.1), lung adult (RPKM 6.6) and 21 other tissues See more
Orthologs
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Genomic context

See Stx11 in Genome Data Viewer
Location:
10 A2; 10 4.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (12813961..12840242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (12938217..12964498, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene utrophin Neighboring gene cofilin-1 pseudogene Neighboring gene RIKEN cDNA B230208H11 gene Neighboring gene STARR-seq mESC enhancer starr_25804 Neighboring gene STARR-positive B cell enhancer ABC_E2928 Neighboring gene nuclear encoded tRNA leucine 3 (anticodon TAA) Neighboring gene STARR-positive B cell enhancer mm9_chr10:12683331-12683631 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:12684154-12684263 Neighboring gene STARR-positive B cell enhancer mm9_chr10:12716948-12717249 Neighboring gene STARR-positive B cell enhancer ABC_E5119 Neighboring gene predicted gene, 57557 Neighboring gene splicing factor 3b, subunit 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in presynaptic active zone membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163590.1NP_001157062.1  syntaxin-11

    See identical proteins and their annotated locations for NP_001157062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL691505
    Consensus CDS
    CCDS48500.1
    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Related
    ENSMUSP00000132758.2, ENSMUST00000163425.9
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  2. NM_001163591.1NP_001157063.1  syntaxin-11

    See identical proteins and their annotated locations for NP_001157063.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AL691505
    Consensus CDS
    CCDS48500.1
    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  3. NM_029075.1NP_083351.1  syntaxin-11

    See identical proteins and their annotated locations for NP_083351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK017897, AK153408, BY753247
    Consensus CDS
    CCDS48500.1
    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Related
    ENSMUSP00000046243.6, ENSMUST00000042861.7
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    12813961..12840242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512886.4XP_006512949.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_006512949.1

    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  2. XM_006512887.4XP_006512950.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_006512950.1

    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif
  3. XM_006512888.5XP_006512951.1  syntaxin-11 isoform X1

    See identical proteins and their annotated locations for XP_006512951.1

    UniProtKB/Swiss-Prot
    Q9D3G5
    UniProtKB/TrEMBL
    Q3TAS3, Q3U5V8
    Conserved Domains (2) summary
    pfam00804
    Location:41238
    Syntaxin
    cl22856
    Location:207273
    SNARE; SNARE motif