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WNT3 Wnt family member 3 [ Homo sapiens (human) ]

Gene ID: 7473, updated on 24-Nov-2020

Summary

Official Symbol
WNT3provided by HGNC
Official Full Name
Wnt family member 3provided by HGNC
Primary source
HGNC:HGNC:12782
See related
Ensembl:ENSG00000108379 MIM:165330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT4; TETAMS
Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 21.7), testis (RPKM 3.1) and 3 other tissues See more
Orthologs

Genomic context

See WNT3 in Genome Data Viewer
Location:
17q21.31-q21.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (46762506..46818692, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (44839872..44896126, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 37 member A2 Neighboring gene N-ethylmaleimide sensitive factor, vesicle fusing ATPase Neighboring gene Sharpr-MPRA regulatory region 12503 Neighboring gene ribosomal protein S7 pseudogene 11 Neighboring gene ZFP161 motif-containing MPRA enhancer 249 Neighboring gene uncharacterized LOC101929777 Neighboring gene Wnt family member 9B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.
GeneReviews: Not available
Identification of a novel Parkinson's disease locus via stratified genome-wide association study.
GeneReviews: Not available
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
GeneReviews: Not available
Multiple common variants for celiac disease influencing immune gene expression.
GeneReviews: Not available
Tetraamelia, autosomal recessive
MedGen: C4012268 OMIM: 273395 GeneReviews: Tetra-Amelia Syndrome
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Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131950, MGC138321, MGC138323

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
receptor ligand activity IC
Inferred by Curator
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Spemann organizer formation at the anterior end of the primitive streak IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
axon guidance IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
dorsal/ventral axis specification IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
gamete generation IEA
Inferred from Electronic Annotation
more info
 
head morphogenesis IEA
Inferred from Electronic Annotation
more info
 
limb bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelium development IEP
Inferred from Expression Pattern
more info
PubMed 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of axon extension involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collateral sprouting in absence of injury IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
Wnt signalosome IC
Inferred by Curator
more info
PubMed 
Wnt signalosome NAS
Non-traceable Author Statement
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome TAS
Traceable Author Statement
more info
 
extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
proto-oncogene Wnt-3
Names
WNT-3 proto-oncogene protein
proto-oncogene Int-4 homolog
wingless-type MMTV integration site family, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008084.2 RefSeqGene

    Range
    5025..61211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_030753.5NP_110380.1  proto-oncogene Wnt-3 precursor

    See identical proteins and their annotated locations for NP_110380.1

    Status: REVIEWED

    Source sequence(s)
    BC114219, CX872929, DB462855
    Consensus CDS
    CCDS11505.1
    UniProtKB/Swiss-Prot
    P56703
    Related
    ENSP00000225512.5, ENST00000225512.6
    Conserved Domains (1) summary
    cd19335
    Location:42355
    Wnt_Wnt3_Wnt3a; Wnt domain found in proto-oncogene Wnt-3 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    46762506..46818692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_167251.2 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1748384..1804419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_187663.1 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    1281918..1338132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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