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MLH1 mutL homolog 1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 747104, updated on 27-Jun-2020

Summary

Official Symbol
MLH1provided by VGNC
Official Full Name
mutL homolog 1provided by VGNC
Primary source
VGNC:VGNC:2049
Locus tag
CK820_G0009056
See related
Ensembl:ENSPTRG00000014743
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs

Genomic context

See MLH1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
20
Annotation release Status Assembly Chr Location
105 current Clint_PTRv2 (GCF_002880755.1) 3 NC_036882.1 (37190570..37262921)
104 previous assembly Pan_tro 3.0 (GCF_000001515.7) 3 NC_006490.4 (37707468..37786860)
103 previous assembly Pan_troglodytes-2.1.4 (GCF_000001515.6) 3 NC_006490.3 (37565788..37639081)

Chromosome 3 - NC_036882.1Genomic Context describing neighboring genes Neighboring gene protease-associated domain-containing protein 1 pseudogene Neighboring gene EPM2A interacting protein 1 Neighboring gene ribosomal protein L29 pseudogene Neighboring gene LRR binding FLII interacting protein 2 Neighboring gene ubiquitin-conjugating enzyme E2 D3 pseudogene Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
DNA mismatch repair protein Mlh1
Names
MutL protein homolog 1
mutL homolog 1, colon cancer, nonpolyposis type 2

NCBI Reference Sequences (RefSeq)

RefSeqs of Annotated Genomes: Pan troglodytes Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Clint_PTRv2 Primary Assembly

Genomic

  1. NC_036882.1 Reference Clint_PTRv2 Primary Assembly

    Range
    37190570..37262921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009445168.2XP_009443443.1  DNA mismatch repair protein Mlh1 isoform X2

    Conserved Domains (4) summary
    cd03483
    Location:211335
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    TIGR00585
    Location:6315
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:501701
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl00075
    Location:31132
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
  2. XM_016940655.2XP_016796144.1  DNA mismatch repair protein Mlh1 isoform X4

    Conserved Domains (3) summary
    cd03483
    Location:194
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    pfam16413
    Location:261515
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19186
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
  3. XM_024355369.1XP_024211137.1  DNA mismatch repair protein Mlh1 isoform X5

    Conserved Domains (1) summary
    pfam16413
    Location:161415
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
  4. XM_024355370.1XP_024211138.1  DNA mismatch repair protein Mlh1 isoform X5

    Conserved Domains (1) summary
    pfam16413
    Location:161415
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
  5. XM_016940658.2XP_016796147.1  DNA mismatch repair protein Mlh1 isoform X4

    Conserved Domains (3) summary
    cd03483
    Location:194
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    pfam16413
    Location:261515
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19186
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
  6. XM_001170433.3XP_001170433.1  DNA mismatch repair protein Mlh1 isoform X1

    See identical proteins and their annotated locations for XP_001170433.1

    UniProtKB/TrEMBL
    H2QMA1
    Related
    ENSPTRP00000025426.4, ENSPTRT00000027570.5
    Conserved Domains (2) summary
    TIGR00585
    Location:6315
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:502756
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
  7. XM_016940656.2XP_016796145.1  DNA mismatch repair protein Mlh1 isoform X4

    Conserved Domains (3) summary
    cd03483
    Location:194
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    pfam16413
    Location:261515
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19186
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
  8. XM_016940657.2XP_016796146.1  DNA mismatch repair protein Mlh1 isoform X4

    Conserved Domains (3) summary
    cd03483
    Location:194
    MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to ...
    pfam16413
    Location:261515
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl28386
    Location:19186
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
  9. XM_009445169.1XP_009443444.1  DNA mismatch repair protein Mlh1 isoform X3

    Conserved Domains (4) summary
    TIGR00585
    Location:6246
    mutl; DNA mismatch repair protein MutL
    pfam16413
    Location:432687
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
    cl00075
    Location:31132
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
    cl02783
    Location:227266
    TopoII_MutL_Trans; MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second ...
  10. XM_024355371.1XP_024211139.1  DNA mismatch repair protein Mlh1 isoform X6

    Conserved Domains (1) summary
    pfam16413
    Location:144398
    Mlh1_C; DNA mismatch repair protein Mlh1 C-terminus
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