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DAGLA diacylglycerol lipase alpha [ Homo sapiens (human) ]

Gene ID: 747, updated on 23-Nov-2021

Summary

Official Symbol
DAGLAprovided by HGNC
Official Full Name
diacylglycerol lipase alphaprovided by HGNC
Primary source
HGNC:HGNC:1165
See related
Ensembl:ENSG00000134780 MIM:614015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSDDR; C11orf11; DAGLALPHA; DAGL(ALPHA)
Summary
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]
Expression
Broad expression in brain (RPKM 6.7), colon (RPKM 2.0) and 20 other tissues See more
Orthologs
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Genomic context

See DAGLA in Genome Data Viewer
Location:
11q12.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (61680184..61747002)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61447863..61514473)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927495 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 11353 Neighboring gene MYRF antisense RNA 1 Neighboring gene myelin regulatory factor Neighboring gene transmembrane protein 258 Neighboring gene microRNA 611

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
GeneReviews: Not available
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
GeneReviews: Not available
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acylglycerol lipase activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in arachidonic acid metabolic process TAS
Traceable Author Statement
more info
 
involved_in diacylglycerol catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in diacylglycerol catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocannabinoid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotransmitter biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neuroinflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in retrograde trans-synaptic signaling by endocannabinoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde trans-synaptic signaling by endocannabinoid ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in varicosity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
diacylglycerol lipase-alpha
Names
DAGL-alpha
DGL-alpha
neural stem cell-derived dendrite regulator
sn1-specific diacylglycerol lipase alpha
NP_006124.1
XP_016873727.1
XP_016873728.1
XP_016873729.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006133.3NP_006124.1  diacylglycerol lipase-alpha

    See identical proteins and their annotated locations for NP_006124.1

    Status: REVIEWED

    Source sequence(s)
    AP002380, BC150176
    Consensus CDS
    CCDS31578.1
    UniProtKB/Swiss-Prot
    Q9Y4D2
    UniProtKB/TrEMBL
    A0A024R517
    Related
    ENSP00000257215.5, ENST00000257215.10
    Conserved Domains (1) summary
    cd00519
    Location:288529
    Lipase_3; Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    61680184..61747002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018238.1XP_016873727.1  diacylglycerol lipase-alpha isoform X1

  2. XM_017018240.1XP_016873729.1  diacylglycerol lipase-alpha isoform X2

  3. XM_017018239.1XP_016873728.1  diacylglycerol lipase-alpha isoform X1

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