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WEE1 WEE1 G2 checkpoint kinase [ Homo sapiens (human) ]

Gene ID: 7465, updated on 1-Jun-2020

Summary

Official Symbol
WEE1provided by HGNC
Official Full Name
WEE1 G2 checkpoint kinaseprovided by HGNC
Primary source
HGNC:HGNC:12761
See related
Ensembl:ENSG00000166483 MIM:193525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEE1A; WEE1hu
Summary
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 23.7), esophagus (RPKM 19.4) and 22 other tissues See more
Orthologs

Genomic context

See WEE1 in Genome Data Viewer
Location:
11p15.4
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (9573670..9589985)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (9595197..9615016)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 143 Neighboring gene CRISPRi-validated cis-regulatory element chr11.1006 Neighboring gene ribosomal protein L23a pseudogene 65 Neighboring gene ribosomal protein L21 pseudogene 97

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr Prolonged cell cycle arrest in the G2 phase induced by HIV-1 Vpr results in the depletion of Wee1 kinase PubMed
vpr HIV-1 Vpr binds to Wee1. Amino acids 291-369 in Wee1 are required for the binding between Vpr and Wee1. Vpr stimulates Wee1 kinase activity PubMed
vpr HIV-1 Vpr-induced cell cycle arrest results in increased levels of Wee-1 kinase in synchronized HeLa cells; G2 arrest by Vpr is correlated with delayed degradation of Wee-1, and Cdc2 activity is reduced at G2/M in the presence of Vpr PubMed
vpr HIV-1 Vpr induced cell cycle arrest in the G2 phase is mediated predominately through the Wee1 kinase in fission yeast PubMed
vpr Overexpression of Wee-1 kinase suppresses HIV-1 Vpr-mediated apoptosis PubMed
vpr Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16446, DKFZp686I18166

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity TAS
Traceable Author Statement
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
neuron projection morphogenesis IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
wee1-like protein kinase
Names
WEE1 homolog
WEE1+ homolog
wee1A kinase
NP_001137448.1
NP_003381.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143976.1NP_001137448.1  wee1-like protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001137448.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a different first exon and 5' UTR, compared to variant 1. This difference causes translation initiation from an in-frame downstream AUG and an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK122837, BQ024511
    Consensus CDS
    CCDS44536.1
    UniProtKB/Swiss-Prot
    P30291
    Related
    ENSP00000299613.5, ENST00000299613.10
    Conserved Domains (2) summary
    cd14138
    Location:79354
    PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a
    pfam00069
    Location:85355
    Pkinase; Protein kinase domain
  2. NM_003390.4NP_003381.1  wee1-like protein kinase isoform 1

    See identical proteins and their annotated locations for NP_003381.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011979, AC122179, BC051831, BQ024511, U10564
    Consensus CDS
    CCDS7800.1
    UniProtKB/Swiss-Prot
    P30291
    UniProtKB/TrEMBL
    Q86V29
    Related
    ENSP00000402084.2, ENST00000450114.7
    Conserved Domains (2) summary
    cd14138
    Location:293568
    PTKc_Wee1a; Catalytic domain of the Protein Tyrosine Kinase, Wee1a
    pfam00069
    Location:299569
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    9573670..9589985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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