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CASP8 caspase 8 [ Pan troglodytes (chimpanzee) ]

Gene ID: 746477, updated on 17-May-2023

Summary

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Official Symbol
CASP8provided by VGNC
Official Full Name
caspase 8provided by VGNC
Primary source
VGNC:VGNC:119
Locus tag
CK820_G0014830
See related
Ensembl:ENSPTRG00000012801
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See CASP8 in Genome Data Viewer
Location:
chromosome: 2B
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_04 current NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 2B NC_072400.1 (103266042..103318044)

Chromosome 2B - NC_072400.1Genomic Context describing neighboring genes Neighboring gene CASP8 and FADD like apoptosis regulator Neighboring gene 60S ribosomal protein L38-like Neighboring gene caspase 10 Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene trafficking kinesin protein 2 Neighboring gene trafficking kinesin protein 2 Neighboring gene STE20 related adaptor beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_072400.1 Chromosome 2B Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

General protein information

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Preferred Names
caspase-8
Names
caspase 8, apoptosis-related cysteine peptidase
XP_001172193.1
XP_009442259.1
XP_009442260.1
XP_009442261.1
XP_009442262.1
XP_009442265.1
XP_009442266.1
XP_009442269.1
XP_009442270.1
XP_016805776.1
XP_016805777.1
XP_016805778.1
XP_054535194.1
XP_054535195.1
XP_054535196.1
XP_054535197.1
XP_054535198.1
XP_054535199.1
XP_054535200.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Genomic

  1. NC_072400.1 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

    Range
    103266042..103318044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009443990.4 → XP_009442265.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_009442265.1

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2R9AE19, A0A6D2VYS4
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_054679219.1 → XP_054535194.1  caspase-8 isoform X6

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2R9AJC1, A0A6D2WZ76

  3. XM_001172193.5 → XP_001172193.1  caspase-8 isoform X1

    See identical proteins and their annotated locations for XP_001172193.1

    UniProtKB/TrEMBL
    A0A2J8N548, A0A6D2WT42, H2QJ86
    Related
    ENSPTRP00000021879.5
    Conserved Domains (3) summary
    cd00032
    Location:284 → 536
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_009443984.4 → XP_009442259.1  caspase-8 isoform X2

    Conserved Domains (3) summary
    cd00032
    Location:269 → 521
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  5. XM_016950288.3 → XP_016805777.1  caspase-8 isoform X7

    Related
    ENSPTRP00000091394.1

  6. XM_009443991.4 → XP_009442266.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_009442266.1

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2R9AE19, A0A6D2VYS4
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  7. XM_009443986.3 → XP_009442261.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_009442261.1

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2R9AE19, A0A6D2VYS4
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  8. XM_054679222.1 → XP_054535197.1  caspase-8 isoform X9

  9. XM_016950289.3 → XP_016805778.1  caspase-8 isoform X9

  10. XM_016950287.3 → XP_016805776.1  caspase-8 isoform X3

  11. XM_054679225.1 → XP_054535200.1  caspase-8 isoform X12

  12. XM_009443985.4 → XP_009442260.1  caspase-8 isoform X4

    Conserved Domains (3) summary
    cd00032
    Location:284 → 495
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:62 → 143
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:157 → 239
    DD; Death Domain Superfamily of protein-protein interaction domains

  13. XM_009443994.3 → XP_009442269.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_009442269.1

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2R9AE19, A0A6D2VYS4
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  14. XM_054679220.1 → XP_054535195.1  caspase-8 isoform X6

    UniProtKB/TrEMBL
    A0A2I3RN77, A0A2R9AJC1, A0A6D2WZ76

  15. XM_009443995.4 → XP_009442270.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_009442270.1

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2R9AE19, A0A6D2VYS4
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  16. XM_009443987.4 → XP_009442262.1  caspase-8 isoform X5

    See identical proteins and their annotated locations for XP_009442262.1

    UniProtKB/TrEMBL
    A0A2I3T6Z1, A0A2R9AE19, A0A6D2VYS4
    Conserved Domains (3) summary
    cd00032
    Location:225 → 477
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08333
    Location:3 → 84
    DED_Caspase_8_r1; Death effector domain, repeat 1, of Caspase-8
    cl14633
    Location:98 → 180
    DD; Death Domain Superfamily of protein-protein interaction domains

  17. XM_054679221.1 → XP_054535196.1  caspase-8 isoform X8

  18. XM_054679223.1 → XP_054535198.1  caspase-8 isoform X10

  19. XM_054679224.1 → XP_054535199.1  caspase-8 isoform X11

Nucleotide Protein
Heading Accession and Version

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