U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HIF1A hypoxia inducible factor 1 subunit alpha [ Pan troglodytes (chimpanzee) ]

Gene ID: 746195, updated on 2-Nov-2023

Summary

Official Symbol
HIF1Aprovided by VGNC
Official Full Name
hypoxia inducible factor 1 subunit alphaprovided by VGNC
Primary source
VGNC:VGNC:8202
Locus tag
CK820_G0002614
See related
Ensembl:ENSPTRG00000006419
Gene type
protein coding
RefSeq status
MODEL
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HIF1A in Genome Data Viewer
Location:
chromosome: 14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_04 current NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 14 NC_072412.1 (52955432..53008337)

Chromosome 14 - NC_072412.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112205384 Neighboring gene transmembrane protein 30B Neighboring gene protein kinase C eta Neighboring gene small nuclear RNA activating complex polypeptide 1 Neighboring gene cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like Neighboring gene synaptotagmin 16

Genomic regions, transcripts, and products

Genomic Sequence:
NC_072412.1 Chromosome 14 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
PubMed 

General protein information

Preferred Names
hypoxia-inducible factor 1-alpha
Names
hypoxia inducible factor 1 alpha subunit
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
small nuclear RNA activating complex, polypeptide 1, 43kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: GCF_028858775.1-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

Genomic

  1. NC_072412.1 Reference NHGRI_mPanTro3-v1.1-hic.freeze_pri

    Range
    52955432..53008337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009427907.3XP_009426182.1  hypoxia-inducible factor 1-alpha isoform X2

    See identical proteins and their annotated locations for XP_009426182.1

    UniProtKB/TrEMBL
    A0A2I3RKE9, A0A2J8PI78, A0A6D2VTV6, K7D4V4
    Related
    ENSPTRP00000078653.1
    Conserved Domains (5) summary
    smart00091
    Location:93148
    PAS; PAS domain
    cd00083
    Location:1568
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08778
    Location:789825
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam08447
    Location:254339
    PAS_3; PAS fold
    pfam11413
    Location:552581
    HIF-1; Hypoxia-inducible factor-1
  2. XM_009427905.3XP_009426180.1  hypoxia-inducible factor 1-alpha isoform X1

    See identical proteins and their annotated locations for XP_009426180.1

    UniProtKB/TrEMBL
    A0A2I3RKE9, A0A2J8PI90
    Conserved Domains (5) summary
    smart00091
    Location:94149
    PAS; PAS domain
    cd00083
    Location:1669
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08778
    Location:790826
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam08447
    Location:255340
    PAS_3; PAS fold
    pfam11413
    Location:553582
    HIF-1; Hypoxia-inducible factor-1
  3. XM_001168948.5XP_001168948.1  hypoxia-inducible factor 1-alpha isoform X6

    See identical proteins and their annotated locations for XP_001168948.1

    UniProtKB/TrEMBL
    A0A2I3RKE9, A0A2J8PI97, A0A6D2W463, K7DRZ3
    Related
    ENSPTRP00000071638.1
    Conserved Domains (4) summary
    smart00091
    Location:93148
    PAS; PAS domain
    cd00083
    Location:1568
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08447
    Location:254339
    PAS_3; PAS fold
    pfam11413
    Location:552581
    HIF-1; Hypoxia-inducible factor-1
  4. XM_009427909.4XP_009426184.1  hypoxia-inducible factor 1-alpha isoform X5

    UniProtKB/TrEMBL
    A0A2I3RKE9
    Conserved Domains (5) summary
    smart00091
    Location:94149
    PAS; PAS domain
    cd00083
    Location:1669
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:240339
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam08447
    Location:255340
    PAS_3; PAS fold
    pfam11413
    Location:552582
    HIF-1; Hypoxia-inducible factor-1
  5. XM_016926181.2XP_016781670.1  hypoxia-inducible factor 1-alpha isoform X3

    UniProtKB/TrEMBL
    A0A2I3SVP9
    Related
    ENSPTRP00000081091.1
  6. XM_024348744.2XP_024204512.1  hypoxia-inducible factor 1-alpha isoform X4

    UniProtKB/TrEMBL
    A0A2I3SVP9
    Conserved Domains (5) summary
    smart00091
    Location:93148
    PAS; PAS domain
    cd00083
    Location:1568
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08778
    Location:748784
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam08447
    Location:254339
    PAS_3; PAS fold
    pfam11413
    Location:515540
    HIF-1; Hypoxia-inducible factor-1
  7. XM_016926182.2XP_016781671.1  hypoxia-inducible factor 1-alpha isoform X7

    UniProtKB/TrEMBL
    A0A2I3RKE9, A0A2J8PI83, A0A6D2WHZ5, H2Q8F3
    Related
    ENSPTRP00000010887.3
    Conserved Domains (5) summary
    smart00091
    Location:117172
    PAS; PAS domain
    cd00083
    Location:3992
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08778
    Location:813849
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam08447
    Location:278363
    PAS_3; PAS fold
    pfam11413
    Location:576605
    HIF-1; Hypoxia-inducible factor-1
  8. XM_024348745.2XP_024204513.1  hypoxia-inducible factor 1-alpha isoform X8

    UniProtKB/TrEMBL
    A0A2I3RKE9
    Conserved Domains (5) summary
    smart00091
    Location:86141
    PAS; PAS domain
    cd00083
    Location:861
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam08778
    Location:782818
    HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain
    pfam08447
    Location:247332
    PAS_3; PAS fold
    pfam11413
    Location:545574
    HIF-1; Hypoxia-inducible factor-1