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Mgme1 mitochondrial genome maintenance exonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 74528, updated on 26-Sep-2022

Summary

Official Symbol
Mgme1provided by MGI
Official Full Name
mitochondrial genome maintenance exonuclease 1provided by MGI
Primary source
MGI:MGI:1921778
See related
Ensembl:ENSMUSG00000027424 AllianceGenome:MGI:1921778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
8430406I07Rik
Summary
Predicted to enable single-stranded DNA exodeoxyribonuclease activity. Predicted to be involved in mitochondrial DNA replication and mitochondrial genome maintenance. Predicted to act upstream of or within DNA repair. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 11. Orthologous to human MGME1 (mitochondrial genome maintenance exonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 5.7), genital fat pad adult (RPKM 4.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mgme1 in Genome Data Viewer
Location:
2; 2 G1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (144112824..144123147)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (144270904..144281227)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sorting nexin 5 Neighboring gene predicted gene, 26165 Neighboring gene small nucleolar RNA, C/D box 17 Neighboring gene ovo like zinc finger 2 Neighboring gene predicted gene, 34181

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA exodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial genome maintenance ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitochondrial genome maintenance exonuclease 1
Names
mitochondrial genome maintainance exonuclease 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289630.1NP_001276559.1  mitochondrial genome maintenance exonuclease 1

    See identical proteins and their annotated locations for NP_001276559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AA866735, AK031535, AK049565, BB040330, BM942022
    Consensus CDS
    CCDS16816.1
    UniProtKB/Swiss-Prot
    Q543Z8, Q9CXC3
    Related
    ENSMUSP00000105654.2, ENSMUST00000110027.2
    Conserved Domains (1) summary
    cl00641
    Location:191324
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
  2. NM_001289631.1NP_001276560.1  mitochondrial genome maintenance exonuclease 1

    See identical proteins and their annotated locations for NP_001276560.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AA866735, AK018387, AK031535, AK159286, BB040330, BM942022
    Consensus CDS
    CCDS16816.1
    UniProtKB/Swiss-Prot
    Q543Z8, Q9CXC3
    Related
    ENSMUSP00000105655.2, ENSMUST00000110028.8
    Conserved Domains (1) summary
    cl00641
    Location:191324
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
  3. NM_001355688.1NP_001342617.1  mitochondrial genome maintenance exonuclease 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AL808123
    Consensus CDS
    CCDS16816.1
    UniProtKB/Swiss-Prot
    Q543Z8
    Conserved Domains (1) summary
    cl00641
    Location:191324
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
  4. NM_028984.5NP_083260.1  mitochondrial genome maintenance exonuclease 1

    See identical proteins and their annotated locations for NP_083260.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AA866735, AK018387, AK031535, BB040330, BM942022, BY136513
    Consensus CDS
    CCDS16816.1
    UniProtKB/Swiss-Prot
    Q543Z8, Q9CXC3
    Related
    ENSMUSP00000028910.3, ENSMUST00000028910.9
    Conserved Domains (1) summary
    cl00641
    Location:191324
    Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    144112824..144123147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)