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Fam234b family with sequence similarity 234, member B [ Mus musculus (house mouse) ]

Gene ID: 74525, updated on 12-May-2024

Summary

Official Symbol
Fam234bprovided by MGI
Official Full Name
family with sequence similarity 234, member Bprovided by MGI
Primary source
MGI:MGI:1921775
See related
Ensembl:ENSMUSG00000030207 AllianceGenome:MGI:1921775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1467; 8430419L09Rik
Summary
Predicted to be located in Golgi apparatus; cytoskeleton; and membrane. Predicted to be integral component of membrane. Is expressed in central nervous system and retina. Orthologous to human FAM234B (family with sequence similarity 234 member B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 38.0), cortex adult (RPKM 37.2) and 26 other tissues See more
Orthologs
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Genomic context

See Fam234b in Genome Data Viewer
Location:
6 G1; 6 66.02 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (135173881..135213240)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (135196880..135236242)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34391 Neighboring gene predicted gene, 19434 Neighboring gene predicted gene, 36533 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:135168385-135168675 Neighboring gene predicted gene, 57750 Neighboring gene STARR-seq mESC enhancer starr_17565 Neighboring gene germ cell associated 1 Neighboring gene predicted gene, 36640 Neighboring gene phosphatidylethanolamine binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

Markers

Clone Names

  • KIAA1467

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362110.1NP_001349039.1  protein FAM234B isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC122820, AC131718
    UniProtKB/TrEMBL
    B2RPZ7
    Conserved Domains (1) summary
    cl11493
    Location:129285
    PQQ_DH_like; PQQ-dependent dehydrogenases and related proteins
  2. NM_001362111.1NP_001349040.1  protein FAM234B isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (3) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122820, AC131718
    UniProtKB/TrEMBL
    B2RPZ7
    Conserved Domains (1) summary
    TIGR03300
    Location:14170
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
  3. NM_028982.4NP_083258.2  protein FAM234B isoform 2

    See identical proteins and their annotated locations for NP_083258.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC131718, AK039401, BC079676
    Consensus CDS
    CCDS39681.1
    UniProtKB/Swiss-Prot
    Q3TE07, Q5DTX5, Q8BYI8, Q8BYJ4, Q9CXB0
    UniProtKB/TrEMBL
    B2RPZ7
    Related
    ENSMUSP00000107546.2, ENSMUST00000111915.8
    Conserved Domains (2) summary
    TIGR03300
    Location:129285
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam13360
    Location:186473
    PQQ_2; PQQ-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    135173881..135213240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506715.4XP_006506778.1  protein FAM234B isoform X1

    UniProtKB/TrEMBL
    B2RPZ7
    Conserved Domains (2) summary
    TIGR03300
    Location:177295
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam13360
    Location:196483
    PQQ_2; PQQ-like domain
  2. XM_030255645.2XP_030111505.1  protein FAM234B isoform X2

    UniProtKB/Swiss-Prot
    Q3TE07, Q5DTX5, Q8BYI8, Q8BYJ4, Q9CXB0
    UniProtKB/TrEMBL
    B2RPZ7
    Conserved Domains (2) summary
    TIGR03300
    Location:129285
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam13360
    Location:186473
    PQQ_2; PQQ-like domain
  3. XM_030255647.1XP_030111507.1  protein FAM234B isoform X4

    UniProtKB/TrEMBL
    B2RPZ7
    Conserved Domains (1) summary
    TIGR03300
    Location:14170
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
  4. XM_030255646.1XP_030111506.1  protein FAM234B isoform X3

    UniProtKB/TrEMBL
    B2RPZ7
    Conserved Domains (2) summary
    TIGR03300
    Location:62180
    assembly_YfgL; outer membrane assembly lipoprotein YfgL
    pfam13360
    Location:81368
    PQQ_2; PQQ-like domain