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VRK1 VRK serine/threonine kinase 1 [ Homo sapiens (human) ]

Gene ID: 7443, updated on 4-Jun-2020

Summary

Official Symbol
VRK1provided by HGNC
Official Full Name
VRK serine/threonine kinase 1provided by HGNC
Primary source
HGNC:HGNC:12718
See related
Ensembl:ENSG00000100749 MIM:602168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCH1; PCH1A
Summary
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008]
Expression
Broad expression in bone marrow (RPKM 15.9), testis (RPKM 12.9) and 23 other tissues See more
Orthologs

Genomic context

See VRK1 in Genome Data Viewer
Location:
14q32.2
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (96797382..96881614)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (97263684..97347951)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370645 Neighboring gene long intergenic non-protein coding RNA 2299 Neighboring gene long intergenic non-protein coding RNA 618 Neighboring gene uncharacterized LOC105370647

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Pontocerebellar hypoplasia type 1A
MedGen: CN032785 OMIM: 607596 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog
Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections.
NHGRI GWA Catalog
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117401, MGC138280, MGC142070

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
histone kinase activity (H3-S10 specific) IDA
Inferred from Direct Assay
more info
PubMed 
histone kinase activity (H3-T3 specific) IDA
Inferred from Direct Assay
more info
PubMed 
nucleosomal histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Golgi disassembly IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
histone H3-S10 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3-T3 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic nuclear envelope disassembly TAS
Traceable Author Statement
more info
 
mitotic nuclear envelope reassembly TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi stack IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase VRK1
Names
vaccinia related kinase 1
vaccinia virus B1R-related kinase 1
NP_003375.1
XP_006720310.1
XP_011535434.1
XP_016877113.1
XP_016877114.1
XP_016877115.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016293.1 RefSeqGene

    Range
    5036..89263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003384.3NP_003375.1  serine/threonine-protein kinase VRK1

    See identical proteins and their annotated locations for NP_003375.1

    Status: REVIEWED

    Source sequence(s)
    AL133168, BU535261, CA436761
    Consensus CDS
    CCDS9947.1
    UniProtKB/Swiss-Prot
    Q99986
    Related
    ENSP00000216639.3, ENST00000216639.8
    Conserved Domains (1) summary
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    96797382..96881614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021624.2XP_016877113.1  serine/threonine-protein kinase VRK1 isoform X3

  2. XM_006720247.4XP_006720310.1  serine/threonine-protein kinase VRK1 isoform X2

    See identical proteins and their annotated locations for XP_006720310.1

    Conserved Domains (2) summary
    smart00220
    Location:37293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1
  3. XM_017021626.2XP_016877115.1  serine/threonine-protein kinase VRK1 isoform X5

  4. XM_017021625.1XP_016877114.1  serine/threonine-protein kinase VRK1 isoform X4

  5. XM_011537132.1XP_011535434.1  serine/threonine-protein kinase VRK1 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:37293
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14122
    Location:26326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RNA

  1. XR_001750539.2 RNA Sequence

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