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Eaf1 ELL associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 74427, updated on 30-Apr-2024

Summary

Official Symbol
Eaf1provided by MGI
Official Full Name
ELL associated factor 1provided by MGI
Primary source
MGI:MGI:1921677
See related
Ensembl:ENSMUSG00000021890 AllianceGenome:MGI:1921677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933403C17Rik
Summary
Predicted to enable transcription elongation regulator activity. Predicted to be involved in positive regulation of transcription, DNA-templated and regulation of transcription elongation from RNA polymerase II promoter. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in intercellular bridge and nuclear body. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human EAF1 (ELL associated factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 21.1), liver E14 (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

See Eaf1 in Genome Data Viewer
Location:
14 B; 14 19.14 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31217036..31231815)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31495079..31509858)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene STARR-seq mESC enhancer starr_36314 Neighboring gene STARR-positive B cell enhancer mm9_chr14:32229701-32230002 Neighboring gene predicted gene, 35907 Neighboring gene STARR-positive B cell enhancer ABC_E7303 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene methyltransferase 6, methylcytidine Neighboring gene STARR-seq mESC enhancer starr_36316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32345029-32345265 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:32369012-32369287 Neighboring gene STARR-seq mESC enhancer starr_36317 Neighboring gene predicted gene, 57482

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription elongation factor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of super elongation complex IEA
Inferred from Electronic Annotation
more info
 
part_of transcription elongation factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of transcription elongation factor complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028932.4NP_083208.1  ELL-associated factor 1

    See identical proteins and their annotated locations for NP_083208.1

    Status: VALIDATED

    Source sequence(s)
    AK036661, AK044181, AK044737
    Consensus CDS
    CCDS26914.1
    UniProtKB/Swiss-Prot
    Q9D4C5
    Related
    ENSMUSP00000022446.6, ENSMUST00000022446.7
    Conserved Domains (1) summary
    pfam09816
    Location:16114
    EAF; RNA polymerase II transcription elongation factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    31217036..31231815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)