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VPREB1 V-set pre-B cell surrogate light chain 1 [ Homo sapiens (human) ]

Gene ID: 7441, updated on 8-Dec-2018

Summary

Official Symbol
VPREB1provided by HGNC
Official Full Name
V-set pre-B cell surrogate light chain 1provided by HGNC
Primary source
HGNC:HGNC:12709
See related
Ensembl:ENSG00000169575 IMGT/GENE-DB:VPREB1; MIM:605141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IGI; IGVPB; VPREB; CD179a
Summary
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Orthologs

Genomic context

See VPREB1 in Genome Data Viewer
Location:
22q11.22
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 22 NC_000022.11 (22244780..22245515)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (22599200..22599926)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene immunoglobulin lambda locus Neighboring gene URI1, prefoldin-like chaperone pseudogene Neighboring gene DNA topoisomerase III beta pseudogene 1 Neighboring gene uncharacterized LOC105372952 Neighboring gene BMS1 pseudogene 20 Neighboring gene immunoglobulin lambda variable 5-52

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
    Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
immunoglobulin iota chain
Names
CD179 antigen-like family member A
pre-B lymphocyte 1
v(pre)B protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000002.1 

    Range
    223181..223916
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. NG_029387.2 RefSeqGene

    Range
    4991..5726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303509.1NP_001290438.1  immunoglobulin iota chain isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC245060
    Consensus CDS
    CCDS77657.1
    UniProtKB/TrEMBL
    F8W8C9
    Related
    ENSP00000304590.2, ENST00000302273.2
    Conserved Domains (2) summary
    smart00410
    Location:25115
    IG_like; Immunoglobulin like
    cl11960
    Location:29117
    Ig; Immunoglobulin domain
  2. NM_007128.3NP_009059.1  immunoglobulin iota chain isoform 1 precursor

    See identical proteins and their annotated locations for NP_009059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC245060, BC017922, BG502270
    Consensus CDS
    CCDS13798.1
    UniProtKB/Swiss-Prot
    P12018
    Related
    ENSP00000385361.3, ENST00000403807.3
    Conserved Domains (2) summary
    smart00410
    Location:26116
    IG_like; Immunoglobulin like
    cl11960
    Location:30118
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p12 Primary Assembly

    Range
    22244780..22245515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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