Format

Send to:

Choose Destination

Specc1l sperm antigen with calponin homology and coiled-coil domains 1-like [ Mus musculus (house mouse) ]

Gene ID: 74392, updated on 8-Dec-2019

Summary

Official Symbol
Specc1lprovided by MGI
Official Full Name
sperm antigen with calponin homology and coiled-coil domains 1-likeprovided by MGI
Primary source
MGI:MGI:1921642
See related
Ensembl:ENSMUSG00000033444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cytsa; AI317249; mKIAA0376; 4930470P14Rik; 4932439K10Rik; 9530057A13Rik
Expression
Ubiquitous expression in lung adult (RPKM 17.1), large intestine adult (RPKM 10.0) and 28 other tissues See more
Orthologs

Genomic context

See Specc1l in Genome Data Viewer
Location:
10; 10 C1
Exon count:
20
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75212037..75312400)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (74674818..74775145)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene RAB36, member RAS oncogene family Neighboring gene predicted gene, 51773 Neighboring gene BCR activator of RhoGEF and GTPase Neighboring gene ATP synthase subunit f, mitochondrial pseudogene Neighboring gene adenosine A2a receptor Neighboring gene ribosomal protein, large, P0 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
face morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of microtubule depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
filamentous actin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
gap junction IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytospin-A
Names
SPECC1-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145826.1NP_001139298.1  cytospin-A isoform a

    See identical proteins and their annotated locations for NP_001139298.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB093236, AI853253, BC072595
    Consensus CDS
    CCDS48598.1
    UniProtKB/Swiss-Prot
    Q2KN98
    UniProtKB/TrEMBL
    A0A0R4J0J8, Q6GQV8
    Related
    ENSMUSP00000101061.3, ENSMUST00000105421.9
    Conserved Domains (4) summary
    COG4942
    Location:410610
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:10331133
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02488
    Location:644820
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21494
    Location:869986
    Abhydrolase; alpha/beta hydrolases
  2. NM_153406.3NP_700455.3  cytospin-A isoform b

    See identical proteins and their annotated locations for NP_700455.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AI853253, AK041543, AY884297, BC072595
    Consensus CDS
    CCDS48599.1
    UniProtKB/Swiss-Prot
    Q2KN98
    UniProtKB/TrEMBL
    Q6GQV8, Q8C9Q9
    Related
    ENSMUSP00000151322.1, ENSMUST00000218766.1
    Conserved Domains (4) summary
    COG4942
    Location:393593
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:10161116
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02488
    Location:627803
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21494
    Location:852969
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

    Range
    75212037..75312400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314127.1XP_017169616.1  cytospin-A isoform X2

    UniProtKB/Swiss-Prot
    Q2KN98
    Conserved Domains (4) summary
    COG4942
    Location:393593
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:10161116
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02488
    Location:627803
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21494
    Location:852969
    Abhydrolase; alpha/beta hydrolases
  2. XM_006514252.4XP_006514315.1  cytospin-A isoform X2

    See identical proteins and their annotated locations for XP_006514315.1

    UniProtKB/Swiss-Prot
    Q2KN98
    Conserved Domains (4) summary
    COG4942
    Location:393593
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:10161116
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02488
    Location:627803
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21494
    Location:852969
    Abhydrolase; alpha/beta hydrolases
  3. XM_030245333.1XP_030101193.1  cytospin-A isoform X2

  4. XM_011243589.2XP_011241891.1  cytospin-A isoform X1

    See identical proteins and their annotated locations for XP_011241891.1

    UniProtKB/Swiss-Prot
    Q2KN98
    UniProtKB/TrEMBL
    A0A0R4J0J8
    Related
    ENSMUSP00000045099.7, ENSMUST00000040105.7
    Conserved Domains (4) summary
    COG4942
    Location:410610
    EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
    cd00014
    Location:10331133
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl02488
    Location:644820
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl21494
    Location:869986
    Abhydrolase; alpha/beta hydrolases
Support Center