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Myo18b myosin XVIIIb [ Mus musculus (house mouse) ]

Gene ID: 74376, updated on 21-Apr-2024

Summary

Official Symbol
Myo18bprovided by MGI
Official Full Name
myosin XVIIIbprovided by MGI
Primary source
MGI:MGI:1921626
See related
Ensembl:ENSMUSG00000072720 AllianceGenome:MGI:1921626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm448; 4932408L24Rik; 4933411E19Rik
Summary
Acts upstream of or within cardiac muscle cell development; in utero embryonic development; and vasculogenesis. Located in Z disc. Part of filamentous actin. Is expressed in several structures, including diaphragm; heart; and musculature. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 4. Orthologous to human MYO18B (myosin XVIIIB). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 19.1), testis adult (RPKM 6.8) and 3 other tissues See more
Orthologs
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Genomic context

Location:
5 F; 5 54.8 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112836742..113044311, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112688876..112896461, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700034G24 gene Neighboring gene VISTA enhancer mm1731 Neighboring gene STARR-seq mESC enhancer starr_14014 Neighboring gene predicted gene, 30529 Neighboring gene RIKEN cDNA 1700095B10 gene Neighboring gene STARR-seq mESC enhancer starr_14016 Neighboring gene G protein-coupled receptor kinase 3 Neighboring gene predicted gene, 22740

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of unconventional myosin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of unconventional myosin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
unconventional myosin-XVIIIb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028901.2NP_083177.2  unconventional myosin-XVIIIb

    See identical proteins and their annotated locations for NP_083177.2

    Status: VALIDATED

    Source sequence(s)
    AC122466, AC149590
    Consensus CDS
    CCDS51618.1
    UniProtKB/TrEMBL
    E9PV66
    Related
    ENSMUSP00000083810.5, ENSMUST00000086617.11
    Conserved Domains (4) summary
    PHA03247
    Location:55472
    PHA03247; large tegument protein UL36; Provisional
    COG5022
    Location:6062126
    COG5022; Myosin heavy chain [General function prediction only]
    cd01386
    Location:6251361
    MYSc_Myo18; class XVIII myosin, motor domain
    pfam15308
    Location:21232365
    CEP170_C; CEP170 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    112836742..113044311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535262.4XP_006535325.1  unconventional myosin-XVIIIb isoform X1

    See identical proteins and their annotated locations for XP_006535325.1

    UniProtKB/TrEMBL
    E9PV66
    Conserved Domains (4) summary
    PHA03247
    Location:55472
    PHA03247; large tegument protein UL36; Provisional
    COG5022
    Location:6062126
    COG5022; Myosin heavy chain [General function prediction only]
    cd01386
    Location:6251361
    MYSc_Myo18; class XVIII myosin, motor domain
    pfam15308
    Location:21232365
    CEP170_C; CEP170 C-terminus