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Rptor regulatory associated protein of MTOR, complex 1 [ Mus musculus (house mouse) ]

Gene ID: 74370, updated on 4-Jun-2024

Summary

Official Symbol
Rptorprovided by MGI
Official Full Name
regulatory associated protein of MTOR, complex 1provided by MGI
Primary source
MGI:MGI:1921620
See related
Ensembl:ENSMUSG00000025583 AllianceGenome:MGI:1921620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rap; Raptor; mKIAA1303; 4932417H02Rik
Summary
This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in adrenal adult (RPKM 14.6), thymus adult (RPKM 13.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rptor in Genome Data Viewer
Location:
11 E2; 11 83.96 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119493731..119790417)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119602905..119899591)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31323 Neighboring gene predicted gene 11762 Neighboring gene neuronal pentraxin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:119464137-119464320 Neighboring gene STARR-seq mESC enhancer starr_31326 Neighboring gene STARR-seq mESC enhancer starr_31328 Neighboring gene STARR-seq mESC enhancer starr_31330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:119695611-119695882 Neighboring gene regulatory associated protein of MTOR, complex 1, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:119718261-119718370 Neighboring gene STARR-positive B cell enhancer ABC_E10735 Neighboring gene STARR-seq mESC enhancer starr_31337 Neighboring gene STARR-positive B cell enhancer ABC_E2379 Neighboring gene predicted gene, 39485 Neighboring gene charged multivesicular body protein 6 Neighboring gene predicted gene 11767

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA damage response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to L-leucine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to nutrient levels ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nutrient levels NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to osmotic stress NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of odontoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of pentose-phosphate shunt NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC1 complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
regulatory-associated protein of mTOR
Names
p150 target of rapamycin (TOR)-scaffold protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306081.1NP_001293010.1  regulatory-associated protein of mTOR isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK144082, AK161011, BC060140
    Conserved Domains (6) summary
    COG2319
    Location:598911
    WD40; WD40 repeat [General function prediction only]
    cd00020
    Location:181250
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:145247
    HEAT_2; HEAT repeats
    sd00044
    Location:95123
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:606642
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:606901
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_028898.3NP_083174.2  regulatory-associated protein of mTOR isoform 1

    See identical proteins and their annotated locations for NP_083174.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK144082, AK161011, BC060140, BC118971
    Consensus CDS
    CCDS25720.1
    UniProtKB/Swiss-Prot
    Q8C9W9, Q8CBY4, Q8CDY8, Q8K4Q0, Q9D4H3
    UniProtKB/TrEMBL
    A2ACM0
    Related
    ENSMUSP00000026671.7, ENSMUST00000026671.13
    Conserved Domains (7) summary
    COG2319
    Location:10191332
    WD40; WD40 repeat [General function prediction only]
    cd00020
    Location:602671
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam13646
    Location:566668
    HEAT_2; HEAT repeats
    pfam14538
    Location:60206
    Raptor_N; Raptor N-terminal CASPase like domain
    sd00044
    Location:516544
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:10271063
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:10271322
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    119493731..119790417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534363.4XP_006534426.1  regulatory-associated protein of mTOR isoform X3

    UniProtKB/Swiss-Prot
    Q8C9W9, Q8CBY4, Q8CDY8, Q8K4Q0, Q9D4H3
    Conserved Domains (6) summary
    COG5096
    Location:390614
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:434462
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:945981
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:55206
    Raptor_N; Raptor N-terminal CASPase like domain
    pfam13646
    Location:484586
    HEAT_2; HEAT repeats
    cl29593
    Location:9451240
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006534361.5XP_006534424.1  regulatory-associated protein of mTOR isoform X1

    UniProtKB/Swiss-Prot
    Q8C9W9, Q8CBY4, Q8CDY8, Q8K4Q0, Q9D4H3
    Conserved Domains (6) summary
    COG5096
    Location:452676
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:496524
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:10071043
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:55206
    Raptor_N; Raptor N-terminal CASPase like domain
    pfam13646
    Location:546648
    HEAT_2; HEAT repeats
    cl29593
    Location:10071302
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006534362.1XP_006534425.1  regulatory-associated protein of mTOR isoform X2

    UniProtKB/TrEMBL
    A4FUW1
    Conserved Domains (6) summary
    COG5096
    Location:418642
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:462490
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:9731009
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:1152
    Raptor_N; Raptor N-terminal CASPase like domain
    pfam13646
    Location:512614
    HEAT_2; HEAT repeats
    cl29593
    Location:9731268
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_036157047.1XP_036012940.1  regulatory-associated protein of mTOR isoform X4

    UniProtKB/TrEMBL
    A4FUW1
    Conserved Domains (6) summary
    COG5096
    Location:324548
    COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    sd00044
    Location:368396
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:879915
    7WD40; WD40 repeat [structural motif]
    pfam13646
    Location:418520
    HEAT_2; HEAT repeats
    pfam14538
    Location:858
    Raptor_N; Raptor N-terminal CASPase like domain
    cl29593
    Location:8791174
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_011249286.4XP_011247588.1  regulatory-associated protein of mTOR isoform X5

    Conserved Domains (4) summary
    sd00044
    Location:3766
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:501537
    7WD40; WD40 repeat [structural motif]
    pfam13646
    Location:40142
    HEAT_2; HEAT repeats
    cl29593
    Location:501796
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_030246393.2XP_030102253.1  regulatory-associated protein of mTOR isoform X5

    Conserved Domains (4) summary
    sd00044
    Location:3766
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:501537
    7WD40; WD40 repeat [structural motif]
    pfam13646
    Location:40142
    HEAT_2; HEAT repeats
    cl29593
    Location:501796
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...