Rptor regulatory associated protein of MTOR, complex 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rptorprovided by MGI
Official Full Name: regulatory associated protein of MTOR, complex 1provided by MGI
Primary source: MGI:MGI:1921620
See related: Ensembl:ENSMUSG00000025583 AllianceGenome:MGI:1921620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rap; Raptor; mKIAA1303; 4932417H02Rik
Summary: This gene encodes a subunit of mammalian target of rapamycin complex 1 (mTORC1), a component of the mTOR signaling pathway, which regulates cell growth in response to nutrient and energy levels. The encoded protein may regulate the assembly, localization, and substrate binding of the mTORC1 complex. Homozygous knockout mice for this gene exhibit embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in adrenal adult (RPKM 14.6), thymus adult (RPKM 13.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11; 11 E2

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (119493731..119790417)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (119602905..119899591)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of regulatory associated protein of TOR (raptor) in hypothalamus-stimulated folliculogenesis and induced ovarian cysts.
Title: Knockdown of regulatory associated protein of TOR (raptor) in hypothalamus-stimulated folliculogenesis and induced ovarian cysts.
Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Title: Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex.
Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy.
Title: Raptor is critical for increasing the mitochondrial proteome and skeletal muscle force during hypertrophy.
Hepatic peroxisomal beta-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.
Title: Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.
AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
Title: AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.
mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner.
Title: mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner.
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-kappaB Activity.
Title: Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
Raptor determines beta-cell identity and plasticity independent of hyperglycemia in mice.
Title: Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice.
These results reveal the cell autonomous requirement for RPTOR in the formation or maintenance of the foundational self-renewing spermatogonial stem cell pool in the mouse testis and underscore complex roles for mTORC1 and its constituent proteins in male germ cell development.
Title: The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.
Ablation of Raptor in neonatal beta-cells led to autonomous loss of cell identity, decelerated cell cycle progression, compromised proliferation, and caused neonatal diabetes as a result of inadequate establishment of functional beta-cell mass at postnatal day 14.
Title: Dual Effect of Raptor on Neonatal β-Cell Proliferation and Identity Maintenance.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (7) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125495 (e-PCR)
- UniSTS:162313

03.MMHAP64FLA3.seq (e-PCR)
- UniSTS:122745

15.MMHAP61FLE3.seq (e-PCR)
- UniSTS:123268

NoName (e-PCR)
- UniSTS:493715

Homology

Homologs of the Rptor gene: The Rptor gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 484 organisms have orthologs with human gene Rptor
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 2 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables TFIIIC-class transcription factor complex binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	NAS Non-traceable Author Statement more info	PubMed
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to osmotic stress	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of autophagy	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of insulin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of lipid biosynthetic process	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of pentose-phosphate shunt	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with dendrite	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
colocalizes_with neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulatory-associated protein of mTOR

Names: p150 target of rapamycin (TOR)-scaffold protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001306081.1 → NP_001293010.1 regulatory-associated protein of mTOR isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in its 5' UTR and uses a downstream in-frame start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK144082, AK161011, BC060140

Conserved Domains (6) summary

COG2319
Location:598 → 911

WD40; WD40 repeat [General function prediction only]

cd00020
Location:181 → 250

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam13646
Location:145 → 247

HEAT_2; HEAT repeats

sd00044
Location:95 → 123

HEAT; HEAT repeat [structural motif]

sd00039
Location:606 → 642

7WD40; WD40 repeat [structural motif]

cl02567
Location:606 → 901

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_028898.3 → NP_083174.2 regulatory-associated protein of mTOR isoform 1

See identical proteins and their annotated locations for NP_083174.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK144082, AK161011, BC060140, BC118971

Consensus CDS

CCDS25720.1

UniProtKB/TrEMBL

A0A8C6HBF7, A2ACM0, A4FUW1

Related

ENSMUSP00000026671.7, ENSMUST00000026671.13

Conserved Domains (7) summary

COG2319
Location:1019 → 1332

WD40; WD40 repeat [General function prediction only]

cd00020
Location:602 → 671

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam13646
Location:566 → 668

HEAT_2; HEAT repeats

pfam14538
Location:60 → 206

Raptor_N; Raptor N-terminal CASPase like domain

sd00044
Location:516 → 544

HEAT; HEAT repeat [structural motif]

sd00039
Location:1027 → 1063

7WD40; WD40 repeat [structural motif]

cl02567
Location:1027 → 1322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

119493731..119790417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534363.4 → XP_006534426.1 regulatory-associated protein of mTOR isoform X3

Conserved Domains (6) summary

COG5096
Location:390 → 614

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:434 → 462

HEAT; HEAT repeat [structural motif]

sd00039
Location:945 → 981

7WD40; WD40 repeat [structural motif]

pfam14538
Location:55 → 206

Raptor_N; Raptor N-terminal CASPase like domain

pfam13646
Location:484 → 586

HEAT_2; HEAT repeats

cl29593
Location:945 → 1240

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006534361.5 → XP_006534424.1 regulatory-associated protein of mTOR isoform X1

UniProtKB/TrEMBL

A0A8C6HBA0

Conserved Domains (6) summary

COG5096
Location:452 → 676

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:496 → 524

HEAT; HEAT repeat [structural motif]

sd00039
Location:1007 → 1043

7WD40; WD40 repeat [structural motif]

pfam14538
Location:55 → 206

Raptor_N; Raptor N-terminal CASPase like domain

pfam13646
Location:546 → 648

HEAT_2; HEAT repeats

cl29593
Location:1007 → 1302

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006534362.1 → XP_006534425.1 regulatory-associated protein of mTOR isoform X2

Conserved Domains (6) summary

COG5096
Location:418 → 642

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:462 → 490

HEAT; HEAT repeat [structural motif]

sd00039
Location:973 → 1009

7WD40; WD40 repeat [structural motif]

pfam14538
Location:1 → 152

Raptor_N; Raptor N-terminal CASPase like domain

pfam13646
Location:512 → 614

HEAT_2; HEAT repeats

cl29593
Location:973 → 1268

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036157047.1 → XP_036012940.1 regulatory-associated protein of mTOR isoform X4

Conserved Domains (6) summary

COG5096
Location:324 → 548

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:368 → 396

HEAT; HEAT repeat [structural motif]

sd00039
Location:879 → 915

7WD40; WD40 repeat [structural motif]

pfam13646
Location:418 → 520

HEAT_2; HEAT repeats

pfam14538
Location:8 → 58

Raptor_N; Raptor N-terminal CASPase like domain

cl29593
Location:879 → 1174

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011249286.4 → XP_011247588.1 regulatory-associated protein of mTOR isoform X5

Conserved Domains (4) summary

sd00044
Location:37 → 66

HEAT; HEAT repeat [structural motif]

sd00039
Location:501 → 537

7WD40; WD40 repeat [structural motif]

pfam13646
Location:40 → 142

HEAT_2; HEAT repeats

cl29593
Location:501 → 796

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_030246393.2 → XP_030102253.1 regulatory-associated protein of mTOR isoform X5

Conserved Domains (4) summary

sd00044
Location:37 → 66

HEAT; HEAT repeat [structural motif]

sd00039
Location:501 → 537

7WD40; WD40 repeat [structural motif]

pfam13646
Location:40 → 142

HEAT_2; HEAT repeats

cl29593
Location:501 → 796

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...