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Mei1 meiotic double-stranded break formation protein 1 [ Mus musculus (house mouse) ]

Gene ID: 74369, updated on 8-Feb-2024

Summary

Official Symbol
Mei1provided by MGI
Official Full Name
meiotic double-stranded break formation protein 1provided by MGI
Primary source
MGI:MGI:3028590
See related
Ensembl:ENSMUSG00000068117 AllianceGenome:MGI:3028590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mei1; 4932408F18Rik
Summary
Acts upstream of or within gamete generation; meiotic spindle organization; and meiotic telomere clustering. Is expressed in brain; ovary; and testis. Human ortholog(s) of this gene implicated in gestational trophoblastic neoplasm. Orthologous to human MEI1 (meiotic double-stranded break formation protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.0), cortex adult (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

See Mei1 in Genome Data Viewer
Location:
15 E1; 15 38.41 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81954275..82011018)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82070074..82126817)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7400 Neighboring gene RIKEN cDNA 4930407I10 gene Neighboring gene SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5) Neighboring gene STARR-seq mESC enhancer starr_39280 Neighboring gene STARR-seq mESC enhancer starr_39281 Neighboring gene STARR-positive B cell enhancer ABC_E8600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:81965919-81966120 Neighboring gene coiled-coil domain containing 134 Neighboring gene STARR-seq mESC enhancer starr_39283 Neighboring gene sterol regulatory element binding factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E5500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:81996613-81996854 Neighboring gene STARR-seq mESC enhancer starr_39286 Neighboring gene microRNA 33

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (other) (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

General protein information

Preferred Names
meiosis inhibitor protein 1
Names
meiosis defective protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310435.1NP_001297364.1  meiosis inhibitor protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001297364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102176, AK016514
    Consensus CDS
    CCDS79396.1
    UniProtKB/Swiss-Prot
    Q9D4I2
    Related
    ENSMUSP00000139689.2, ENSMUST00000188048.7
  2. NM_028897.3NP_083173.2  meiosis inhibitor protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102176, AK016514, BY641487
    Consensus CDS
    CCDS88810.1
    UniProtKB/Swiss-Prot
    B2RQ44, F8WHB9, Q9D4I2
    UniProtKB/TrEMBL
    A0A2R8VHD2
    Related
    ENSMUSP00000086582.6, ENSMUST00000089178.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81954275..82011018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521494.4XP_006521557.1  meiosis inhibitor protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A2R8VHD2
  2. XM_006521495.4XP_006521558.1  meiosis inhibitor protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHD2
  3. XM_017316770.2XP_017172259.1  meiosis inhibitor protein 1 isoform X4

  4. XM_006521496.5XP_006521559.1  meiosis inhibitor protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006521559.1

    UniProtKB/TrEMBL
    A0A2R8VHD2
  5. XM_030248803.2XP_030104663.1  meiosis inhibitor protein 1 isoform X5