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Lonrf3 LON peptidase N-terminal domain and ring finger 3 [ Mus musculus (house mouse) ]

Gene ID: 74365, updated on 8-May-2024

Summary

Official Symbol
Lonrf3provided by MGI
Official Full Name
LON peptidase N-terminal domain and ring finger 3provided by MGI
Primary source
MGI:MGI:1921615
See related
Ensembl:ENSMUSG00000016239 AllianceGenome:MGI:1921615
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf127; 4932412G04Rik; 5730439E01Rik; A830039N02Rik
Summary
Predicted to enable metal ion binding activity. Is expressed in telencephalon mantle layer and telencephalon ventricular layer. Orthologous to human LONRF3 (LON peptidase N-terminal domain and ring finger 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 2.7), placenta adult (RPKM 2.6) and 26 other tissues See more
Orthologs
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Genomic context

See Lonrf3 in Genome Data Viewer
Location:
X A3.3; X 20.72 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (35592011..35630510)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (36328358..36366857)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 42406 Neighboring gene STARR-seq mESC enhancer starr_46996 Neighboring gene zinc finger, CCHC domain containing 12 Neighboring gene predicted gene 6023 Neighboring gene predicted gene, 25047 Neighboring gene predicted gene, 22364 Neighboring gene cancer/testis antigen 47

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
LON peptidase N-terminal domain and RING finger protein 3
Names
ring finger protein 127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028894.1NP_083170.1  LON peptidase N-terminal domain and RING finger protein 3

    See identical proteins and their annotated locations for NP_083170.1

    Status: VALIDATED

    Source sequence(s)
    AK016522, AL450395, BC058671, BY740851
    Consensus CDS
    CCDS30059.1
    UniProtKB/Swiss-Prot
    Q9D4H7
    Related
    ENSMUSP00000016383.4, ENSMUST00000016383.10
    Conserved Domains (7) summary
    COG5152
    Location:340498
    COG5152; Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]
    cd00162
    Location:460499
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl19481
    Location:560746
    LON; Found in ATP-dependent protease La (LON)
    sd00006
    Location:244272
    TPR; TPR repeat [structural motif]
    pfam02190
    Location:549750
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
    pfam13414
    Location:243309
    TPR_11; TPR repeat
    pfam14634
    Location:158197
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    35592011..35630510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541404.1XP_006541467.1  LON peptidase N-terminal domain and RING finger protein 3 isoform X1

    Conserved Domains (6) summary
    COG5574
    Location:456551
    PEX10; RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    TIGR00990
    Location:244359
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:244272
    TPR; TPR repeat [structural motif]
    cd16513
    Location:159197
    RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    cd16514
    Location:510551
    RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
    pfam02190
    Location:601802
    LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain