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Spag17 sperm associated antigen 17 [ Mus musculus (house mouse) ]

Gene ID: 74362, updated on 12-May-2026
Official Symbol
Spag17provided by MGI
Official Full Name
sperm associated antigen 17provided by MGI
Primary source
MGI:MGI:1921612
See related
Ensembl:ENSMUSG00000027867 AllianceGenome:MGI:1921612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PF6; Spag17-ps; 4931427F14Rik
Summary
Involved in intramanchette transport; manchette assembly; and motile cilium assembly. Acts upstream of or within axonemal central apparatus assembly; epithelial cilium movement involved in extracellular fluid movement; and establishment of localization in cell. Located in Golgi apparatus; acrosomal vesicle; and cytoskeleton. Is expressed in several structures, including alimentary system; genitourinary system; nasal cavity respiratory epithelium; respiratory system; and spinal cord. Human ortholog(s) of this gene implicated in spermatogenic failure 55. Orthologous to human SPAG17 (sperm associated antigen 17). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in testis adult (RPKM 17.1) and lung adult (RPKM 0.4) See more
Orthologs
all
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Try the new Transcripts and proteins table
See Spag17 in Genome Data Viewer
Location:
3 F2.2; 3 43.25 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (99792653..100050638)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (99885417..100143322)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08486 Neighboring gene mannose-6-phosphate receptor, pseudogene Neighboring gene STARR-seq mESC enhancer starr_08487 Neighboring gene STARR-seq mESC enhancer starr_08488 Neighboring gene STARR-seq mESC enhancer starr_08489 Neighboring gene predicted gene, 22505 Neighboring gene STARR-seq mESC enhancer starr_08490 Neighboring gene ribosomal protein L36, pseudogene 7 Neighboring gene STARR-seq mESC enhancer starr_08491 Neighboring gene STARR-positive B cell enhancer ABC_E6088 Neighboring gene WD repeat domain 3 Neighboring gene ganglioside-induced differentiation-associated-protein 2 Neighboring gene predicted gene, 25802

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice. Abdelhamed Z, et al. Dis Model Mech, 2020 Oct 30. PMID 32988999, Free PMC Article
  2. SPAG17 mediates nuclear translocation of protamines during spermiogenesis. Agudo-Rios C, et al. Front Cell Dev Biol, 2023. PMID 37766963, Free PMC Article
  3. Spag17 deficiency results in skeletal malformations and bone abnormalities. Teves ME, et al. PLoS One, 2015. PMID 26017218, Free PMC Article
  4. SPAG17 Is Required for Male Germ Cell Differentiation and Fertility. Kazarian E, et al. Int J Mol Sci, 2018 Apr 21. PMID 29690537, Free PMC Article
  5. Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival. Teves ME, et al. Am J Respir Cell Mol Biol, 2013 Jun. PMID 23418344, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.
    Title: A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.
  2. Results show for the first time that Spag17 is essential for normal manchette structure, protein transport, and formation of the sperm head and flagellum, in addition to its role in sperm motility.
    Title: SPAG17 Is Required for Male Germ Cell Differentiation and Fertility.
  3. Spag17 plays a role in skeletal growth and mineralization.Spag17 deficiency results in skeletal malformations and bone abnormalities.
    Title: Spag17 deficiency results in skeletal malformations and bone abnormalities.
  4. Deletion of Spag17 gene expression results in hydrocephalus and pulmonary and nasal mucus and fluid congestion.
    Title: Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival.
Submit: New GeneRIF Correction

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonemal central apparatus assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within axonemal central apparatus assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelial cilium movement involved in extracellular fluid movement IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intramanchette transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in manchette assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in axonemal central apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axonemal central apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal central apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
sperm-associated antigen 17
Names
projection protein PF6 homolog
sperm associated antigen 17, pseudogene

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028892.4 → NP_083168.3  sperm-associated antigen 17

    See identical proteins and their annotated locations for NP_083168.3

    Status: VALIDATED

    Source sequence(s)
    AC102209, AK029691, AK029947, AK136364, AL606749, AY792594, BX639948
    Consensus CDS
    CCDS57248.1
    UniProtKB/Swiss-Prot
    G3UYF7, Q3UWG8, Q5S003, Q6Q758, Q8CDR5, Q9CUE5
    Related
    ENSMUSP00000134066.2, ENSMUST00000164539.2
    Conserved Domains (1) summary
    pfam14874
    Location:2173 → 2239
    PapD-like; Flagellar-associated PapD-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    99792653..100050638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163362.1 → XP_036019255.1  sperm-associated antigen 17 isoform X1

    Conserved Domains (1) summary
    pfam14874
    Location:2023 → 2089
    PapD-like; Flagellar-associated PapD-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5S003.2 GenPept UniProtKB/Swiss-Prot:Q5S003

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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