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Fhip1b FHF complex subunit HOOK interacting protein 1B [ Mus musculus (house mouse) ]

Gene ID: 74349, updated on 26-Sep-2022

Summary

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Official Symbol
Fhip1bprovided by MGI
Official Full Name
FHF complex subunit HOOK interacting protein 1Bprovided by MGI
Primary source
MGI:MGI:1921599
See related
Ensembl:ENSMUSG00000044465 AllianceGenome:MGI:1921599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FHIP; Fam160a2; 4632419K20Rik; 6530415H11Rik
Summary
Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to act upstream of or within protein transport. Predicted to be part of FHF complex. Orthologous to human FHIP1B (FHF complex subunit HOOK interacting protein 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.1), colon adult (RPKM 9.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Fhip1b in Genome Data Viewer
Location:
7; 7 E3
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105020418..105049349, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105371211..105400142, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 52 subfamily B member 2 Neighboring gene olfactory receptor family 52 subfamily W member 1 Neighboring gene predicted gene 5901 Neighboring gene cyclic nucleotide gated channel alpha 4 Neighboring gene predicted gene 4972 Neighboring gene cholecystokinin B receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in endosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome to lysosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of FHF complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of FHF complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FHF complex subunit HOOK interacting protein 1B; FTS and Hook-interacting protein
Names
family with sequence similarity 160, member A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242363.2 → NP_001229292.1  FHF complex subunit HOOK interacting protein 1B isoform a

    See identical proteins and their annotated locations for NP_001229292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC125055, AK085350, AK159716, BY309982, CJ102928
    Consensus CDS
    CCDS21649.1
    UniProtKB/Swiss-Prot
    Q3U2I3, Q8VE55
    UniProtKB/TrEMBL
    J3QP99
    Related
    ENSMUSP00000112711.2, ENSMUST00000122327.7
    Conserved Domains (2) summary
    PHA03321
    Location:459 → 585
    PHA03321; tegument protein VP11/12; Provisional
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  2. NM_001242364.2 → NP_001229293.1  FHF complex subunit HOOK interacting protein 1B isoform b

    See identical proteins and their annotated locations for NP_001229293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) is the longest isoform and contains an alternate internal segment compared to isoform a.
    Source sequence(s)
    AC125055, AK085350, AK159716, BE861154, BY309982
    Consensus CDS
    CCDS57574.1
    UniProtKB/Swiss-Prot
    Q3U2I3
    UniProtKB/TrEMBL
    A0A1C7CYU5
    Related
    ENSMUSP00000045084.8, ENSMUST00000048079.14
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  3. NM_001242365.2 → NP_001229294.1  FHF complex subunit HOOK interacting protein 1B isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has alternate in-frame splice junctions at the 3' ends of two exons compared to variant 1. The resulting isoform (c) contains an alternate internal segment and lacks another alternate internal segment compared to isoform a.
    Source sequence(s)
    AC125055, AK159716, BY309982
    Consensus CDS
    CCDS57575.1
    UniProtKB/Swiss-Prot
    Q3U2I3
    Related
    ENSMUSP00000112605.2, ENSMUST00000118726.8
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  4. NM_199009.3 → NP_950174.1  FHF complex subunit HOOK interacting protein 1B isoform a

    See identical proteins and their annotated locations for NP_950174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC125055, BC063093, BY309982
    Consensus CDS
    CCDS21649.1
    UniProtKB/Swiss-Prot
    Q3U2I3, Q8VE55
    UniProtKB/TrEMBL
    J3QP99
    Related
    ENSMUSP00000137163.3, ENSMUST00000179474.9
    Conserved Domains (2) summary
    PHA03321
    Location:459 → 585
    PHA03321; tegument protein VP11/12; Provisional
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105020418..105049349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243034.1 → XP_030098894.1  FTS and Hook-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYU5
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  2. XM_030243035.2 → XP_030098895.1  FTS and Hook-interacting protein isoform X3

    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  3. XM_006508251.5 → XP_006508314.1  FTS and Hook-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_006508314.1

    UniProtKB/TrEMBL
    A0A1C7CYU5
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  4. XM_030243038.2 → XP_030098898.1  FTS and Hook-interacting protein isoform X5

  5. XM_036153501.1 → XP_036009394.1  FTS and Hook-interacting protein isoform X4

  6. XM_030243033.2 → XP_030098893.1  FTS and Hook-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYU5
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  7. XM_036153500.1 → XP_036009393.1  FTS and Hook-interacting protein isoform X2

    UniProtKB/Swiss-Prot
    Q8VE55
    Conserved Domains (2) summary
    PHA03321
    Location:459 → 585
    PHA03321; tegument protein VP11/12; Provisional
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  8. XM_030243036.2 → XP_030098896.1  FTS and Hook-interacting protein isoform X4

  9. XM_030243037.2 → XP_030098897.1  FTS and Hook-interacting protein isoform X4

  10. XM_030243032.2 → XP_030098892.1  FTS and Hook-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYU5
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

  11. XM_036153499.1 → XP_036009392.1  FTS and Hook-interacting protein isoform X1

    UniProtKB/TrEMBL
    A0A1C7CYU5
    Conserved Domains (1) summary
    pfam10257
    Location:97 → 426
    RAI16-like; Retinoic acid induced 16-like protein

RNA

  1. XR_001778008.3 RNA Sequence

  2. XR_003946573.2 RNA Sequence

  3. XR_378277.4 RNA Sequence

  4. XR_004934198.1 RNA Sequence

  5. XR_004934196.1 RNA Sequence

  6. XR_004934197.1 RNA Sequence

  7. XR_004934195.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U2I3.2 GenPept UniProtKB/Swiss-Prot:Q3U2I3

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