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Ahcyl2 S-adenosylhomocysteine hydrolase-like 2 [ Mus musculus (house mouse) ]

Gene ID: 74340, updated on 5-Mar-2024

Summary

Official Symbol
Ahcyl2provided by MGI
Official Full Name
S-adenosylhomocysteine hydrolase-like 2provided by MGI
Primary source
MGI:MGI:1921590
See related
Ensembl:ENSMUSG00000029772 AllianceGenome:MGI:1921590
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0828; Adohcyase3; 4631427C17Rik
Summary
Predicted to enable hydrolase activity. Predicted to be involved in S-adenosylmethionine cycle. Predicted to act upstream of or within one-carbon metabolic process. Located in cytosol; intracellular membrane-bounded organelle; and neuron projection. Is expressed in several structures, including alimentary system; central nervous system; nose; respiratory system; and urinary system. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 28.3), kidney adult (RPKM 23.9) and 28 other tissues See more
Orthologs
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Genomic context

See Ahcyl2 in Genome Data Viewer
Location:
6 A3.3; 6 12.36 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29768378..29912309)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29768379..29912310)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tetraspanin 33 Neighboring gene STARR-positive B cell enhancer ABC_E677 Neighboring gene smoothened, frizzled class receptor Neighboring gene predicted gene 13717 Neighboring gene STARR-seq mESC enhancer starr_15451 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29783505-29783805 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29787542-29787842 Neighboring gene STARR-positive B cell enhancer mm9_chr6:29788430-29788731 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847059-29847242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29847325-29847478 Neighboring gene STARR-positive B cell enhancer ABC_E4816 Neighboring gene striatin interacting protein 2 Neighboring gene predicted gene, 52897 Neighboring gene phosphoglycerate kinase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0828

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenosylhomocysteinase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
putative adenosylhomocysteinase 3
Names
S-adenosyl-L-homocysteine hydrolase 3
S-adenosylhomocysteine hydrolase-like protein 2
adenosylhomocysteinase 3
clone MNCb-5555
long-IRBIT
NP_001164471.2
NP_001164472.1
NP_001334013.1
NP_067389.5
XP_006505242.2
XP_006505243.2
XP_006505244.1
XP_006505245.1
XP_006505246.1
XP_011239384.1
XP_030111502.1
XP_030111503.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171000.2NP_001164471.2  putative adenosylhomocysteinase 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC059255, BC079660, BY733512, CA751283
    Consensus CDS
    CCDS57416.1
    UniProtKB/TrEMBL
    F8WGT1
    Related
    ENSMUSP00000100060.3, ENSMUST00000102995.9
    Conserved Domains (1) summary
    pfam05221
    Location:186611
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  2. NM_001171001.1NP_001164472.1  putative adenosylhomocysteinase 3 isoform 3

    See identical proteins and their annotated locations for NP_001164472.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at an alternate start codon, and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK053527, BC059255, BC079660, CF745122
    Consensus CDS
    CCDS51738.1
    UniProtKB/TrEMBL
    Q80TQ9
    Related
    ENSMUSP00000110893.4, ENSMUST00000115238.10
    Conserved Domains (1) summary
    smart00996
    Location:84507
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  3. NM_001347084.1NP_001334013.1  putative adenosylhomocysteinase 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains alternate exons in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC079216
    Consensus CDS
    CCDS85024.1
    UniProtKB/TrEMBL
    F8WI65, Q80TQ9
    Related
    ENSMUSP00000067638.7, ENSMUST00000064872.13
    Conserved Domains (1) summary
    smart00996
    Location:84507
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  4. NM_021414.6NP_067389.5  putative adenosylhomocysteinase 3 isoform 1

    See identical proteins and their annotated locations for NP_067389.5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC059255, BC079660, BY733512
    Consensus CDS
    CCDS19966.3
    UniProtKB/Swiss-Prot
    Q68FL4, Q8BIH1
    Related
    ENSMUSP00000110897.3, ENSMUST00000115242.9
    Conserved Domains (1) summary
    pfam05221
    Location:187612
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29768378..29912309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241082.3XP_011239384.1  putative adenosylhomocysteinase 3 isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:226529
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. XM_030255642.1XP_030111502.1  putative adenosylhomocysteinase 3 isoform X7

    UniProtKB/TrEMBL
    H3BKT5, Q80TQ9
    Related
    ENSMUSP00000135518.2, ENSMUST00000125911.9
    Conserved Domains (1) summary
    smart00996
    Location:1403
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  3. XM_030255643.2XP_030111503.1  putative adenosylhomocysteinase 3 isoform X7

    UniProtKB/TrEMBL
    H3BKT5, Q80TQ9
    Conserved Domains (1) summary
    smart00996
    Location:1403
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  4. XM_006505182.4XP_006505245.1  putative adenosylhomocysteinase 3 isoform X5

    See identical proteins and their annotated locations for XP_006505245.1

    UniProtKB/TrEMBL
    Q80TQ9
    Conserved Domains (1) summary
    smart00996
    Location:85508
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  5. XM_006505181.4XP_006505244.1  putative adenosylhomocysteinase 3 isoform X4

    UniProtKB/TrEMBL
    Q80TQ9
    Conserved Domains (1) summary
    smart00996
    Location:102525
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  6. XM_006505183.4XP_006505246.1  putative adenosylhomocysteinase 3 isoform X6

    See identical proteins and their annotated locations for XP_006505246.1

    UniProtKB/TrEMBL
    Q80TQ9
    Conserved Domains (1) summary
    smart00996
    Location:85508
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  7. XM_006505179.2XP_006505242.2  putative adenosylhomocysteinase 3 isoform X1

    UniProtKB/TrEMBL
    Q80TQ9
    Conserved Domains (1) summary
    smart00996
    Location:82505
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
  8. XM_006505180.2XP_006505243.2  putative adenosylhomocysteinase 3 isoform X2

    UniProtKB/TrEMBL
    Q80TQ9
    Related
    ENSMUST00000149816.8
    Conserved Domains (1) summary
    smart00996
    Location:81504
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase