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VIP vasoactive intestinal peptide [ Homo sapiens (human) ]

Gene ID: 7432, updated on 8-Jul-2018
Official Symbol
VIPprovided by HGNC
Official Full Name
vasoactive intestinal peptideprovided by HGNC
Primary source
HGNC:HGNC:12693
See related
Ensembl:ENSG00000146469 MIM:192320; Vega:OTTHUMG00000015851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHM27
Summary
The protein encoded by this gene belongs to the glucagon family. It stimulates myocardial contractility, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2014]
Expression
Biased expression in appendix (RPKM 33.5), colon (RPKM 12.6) and 3 other tissues See more
Orthologs
See VIP in Genome Data Viewer
Location:
6q25.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (152750797..152759765)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (153071932..153080900)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378061 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 16 Neighboring gene MYC target 1 Neighboring gene uncharacterized LOC105378065 Neighboring gene tubulin beta 4B class IVb pseudogene 7

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env VIP is more potent at suppressing M-tropic than T-tropic HIV-1 gp120 chemotaxis PubMed
env Vasoactive intestinal peptide (VIP) blocks HIV-1 gp120-induced neurotoxicity in culture PubMed

Go to the HIV-1, Human Interaction Database

  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Gastric acid production, organism-specific biosystem (from WikiPathways)
    Gastric acid production, organism-specific biosystemGastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate...
  • IL-6 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-6 signaling pathway, organism-specific biosystemIL-6 is a pleiotropic cytokine with important role in immune regulation, hematopoiesis, inflammation and oncogenesis. IL-6-type cytokines exert their action via the signal transducer gp130 that assoc...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC13587

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity TAS
Traceable Author Statement
more info
PubMed 
peptide hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
body fluid secretion TAS
Traceable Author Statement
more info
PubMed 
epinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
learning or memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of potassium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of smooth muscle cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of blood vessel diameter IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of endothelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of epinephrine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of penile erection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
prolactin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
VIP peptides
Names
prepro-VIP

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003381.3NP_003372.1  VIP peptides isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_003372.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009794, BM971673, DA914915
    Consensus CDS
    CCDS5240.1
    UniProtKB/Swiss-Prot
    P01282
    Related
    ENSP00000356213.3, OTTHUMP00000017450, ENST00000367244.7, OTTHUMT00000042751
    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone
  2. NM_194435.2NP_919416.1  VIP peptides isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_919416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC009794, BM971673, DA914915
    Consensus CDS
    CCDS5241.1
    UniProtKB/Swiss-Prot
    P01282
    Related
    ENSP00000356212.3, OTTHUMP00000017451, ENST00000367243.7, OTTHUMT00000042752
    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    152750797..152759765
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715562.4XP_006715625.1  VIP peptides isoform X1

    See identical proteins and their annotated locations for XP_006715625.1

    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone
  2. XM_005267135.3XP_005267192.1  VIP peptides isoform X2

    See identical proteins and their annotated locations for XP_005267192.1

    Conserved Domains (1) summary
    pfam00123
    Location:81107
    Hormone_2; Peptide hormone
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