U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Osbp2 oxysterol binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 74309, updated on 11-Apr-2024

Summary

Official Symbol
Osbp2provided by MGI
Official Full Name
oxysterol binding protein 2provided by MGI
Primary source
MGI:MGI:1921559
See related
Ensembl:ENSMUSG00000020435 AllianceGenome:MGI:1921559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm244; ORP-4; OSBPL1; 1700095P05Rik; C630001G20Rik
Summary
The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of cholesterol that are involved in mechanisms that include apoptosis, cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in testis adult (RPKM 125.0), cortex adult (RPKM 12.5) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Osbp2 in Genome Data Viewer
Location:
11 A1; 11 2.6 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3653731..3814000, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3703731..3863999, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6944 Neighboring gene STARR-seq mESC enhancer starr_28362 Neighboring gene microrchidia 2A Neighboring gene STARR-seq mESC enhancer starr_28363 Neighboring gene nucleolar and spindle associated protein 1 pseudogene Neighboring gene predicted gene, 51881 Neighboring gene predicted gene, 51882 Neighboring gene predicted gene, 24013 Neighboring gene STARR-seq mESC enhancer starr_28364 Neighboring gene predicted gene, 51880 Neighboring gene STARR-seq mESC enhancer starr_28365 Neighboring gene STARR-positive B cell enhancer ABC_E8382 Neighboring gene RIKEN cDNA 4921536K21 gene Neighboring gene nucleolar protein 8 pseudogene Neighboring gene dual specificity phosphatase 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatid development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
oxysterol-binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302630.2NP_001289559.1  oxysterol-binding protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001289559.1

    Status: VALIDATED

    Source sequence(s)
    BC058356, BC058602, CV784397
    Consensus CDS
    CCDS78912.1
    UniProtKB/TrEMBL
    Q5QNQ4, Q8K0C7
    Related
    ENSMUSP00000100015.4, ENSMUST00000102950.10
    Conserved Domains (1) summary
    pfam01237
    Location:66435
    Oxysterol_BP; Oxysterol-binding protein
  2. NM_001302631.2NP_001289560.1  oxysterol-binding protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK044598, AL731853, BC058356, CV784397
    UniProtKB/TrEMBL
    Q5QNQ4
    Related
    ENSMUSP00000099156.4, ENSMUST00000101632.4
    Conserved Domains (1) summary
    pfam01237
    Location:108478
    Oxysterol_BP; Oxysterol-binding protein
  3. NM_001363163.1NP_001350092.1  oxysterol-binding protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL691413, AL731853
    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:522891
    Oxysterol_BP; Oxysterol-binding protein
  4. NM_001363164.1NP_001350093.1  oxysterol-binding protein 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL691413, AL731853
    UniProtKB/TrEMBL
    Q5QNQ4, Q6PE09
    Conserved Domains (1) summary
    pfam01237
    Location:155530
    Oxysterol_BP; Oxysterol-binding protein
  5. NM_152818.3NP_690031.2  oxysterol-binding protein 2 isoform 1

    See identical proteins and their annotated locations for NP_690031.2

    Status: VALIDATED

    Source sequence(s)
    AK049816, BC058356
    Consensus CDS
    CCDS24367.1
    UniProtKB/Swiss-Prot
    Q5QNQ6, Q8CF21
    Related
    ENSMUSP00000068652.8, ENSMUST00000070552.14
    Conserved Domains (3) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam00169
    Location:182271
    PH; PH domain
    pfam01237
    Location:519888
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3653731..3814000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514851.5XP_006514914.1  oxysterol-binding protein 2 isoform X11

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:519895
    Oxysterol_BP; Oxysterol-binding protein
  2. XM_011243765.3XP_011242067.1  oxysterol-binding protein 2 isoform X9

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:519900
    Oxysterol_BP; Oxysterol-binding protein
  3. XM_006514849.5XP_006514912.1  oxysterol-binding protein 2 isoform X10

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:522898
    Oxysterol_BP; Oxysterol-binding protein
  4. XM_011243763.3XP_011242065.1  oxysterol-binding protein 2 isoform X6

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:522903
    Oxysterol_BP; Oxysterol-binding protein
  5. XM_036157045.1XP_036012938.1  oxysterol-binding protein 2 isoform X8

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:526901
    Oxysterol_BP; Oxysterol-binding protein
  6. XM_036157044.1XP_036012937.1  oxysterol-binding protein 2 isoform X7

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:526902
    Oxysterol_BP; Oxysterol-binding protein
  7. XM_036157041.1XP_036012934.1  oxysterol-binding protein 2 isoform X3

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:526907
    Oxysterol_BP; Oxysterol-binding protein
  8. XM_036157043.1XP_036012936.1  oxysterol-binding protein 2 isoform X5

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:529904
    Oxysterol_BP; Oxysterol-binding protein
  9. XM_036157042.1XP_036012935.1  oxysterol-binding protein 2 isoform X4

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:529905
    Oxysterol_BP; Oxysterol-binding protein
  10. XM_036157040.1XP_036012933.1  oxysterol-binding protein 2 isoform X2

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:529909
    Oxysterol_BP; Oxysterol-binding protein
  11. XM_036157039.1XP_036012932.1  oxysterol-binding protein 2 isoform X1

    Conserved Domains (2) summary
    cd13284
    Location:182278
    PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
    pfam01237
    Location:529910
    Oxysterol_BP; Oxysterol-binding protein
  12. XM_030246382.1XP_030102242.1  oxysterol-binding protein 2 isoform X12

    Conserved Domains (2) summary
    pfam01237
    Location:323704
    Oxysterol_BP; Oxysterol-binding protein
    cl17171
    Location:1379
    PH-like; Pleckstrin homology-like domain
  13. XM_011243769.3XP_011242071.1  oxysterol-binding protein 2 isoform X24

    See identical proteins and their annotated locations for XP_011242071.1

    UniProtKB/TrEMBL
    Q5QNQ4
    Conserved Domains (1) summary
    pfam01237
    Location:158539
    Oxysterol_BP; Oxysterol-binding protein
  14. XM_030246389.2XP_030102249.1  oxysterol-binding protein 2 isoform X25

    UniProtKB/TrEMBL
    Q5QNQ4
    Conserved Domains (1) summary
    pfam01237
    Location:155536
    Oxysterol_BP; Oxysterol-binding protein
  15. XM_030246391.1XP_030102251.1  oxysterol-binding protein 2 isoform X27

    UniProtKB/TrEMBL
    Q5QNQ4, Q6PE09
    Conserved Domains (1) summary
    pfam01237
    Location:155530
    Oxysterol_BP; Oxysterol-binding protein
  16. XM_011243771.2XP_011242073.1  oxysterol-binding protein 2 isoform X24

    See identical proteins and their annotated locations for XP_011242073.1

    UniProtKB/TrEMBL
    Q5QNQ4
    Conserved Domains (1) summary
    pfam01237
    Location:158539
    Oxysterol_BP; Oxysterol-binding protein
  17. XM_030246390.1XP_030102250.1  oxysterol-binding protein 2 isoform X26

    UniProtKB/TrEMBL
    Q5QNQ4
    Conserved Domains (1) summary
    pfam01237
    Location:155531
    Oxysterol_BP; Oxysterol-binding protein
  18. XM_011243770.3XP_011242072.1  oxysterol-binding protein 2 isoform X24

    See identical proteins and their annotated locations for XP_011242072.1

    UniProtKB/TrEMBL
    Q5QNQ4
    Conserved Domains (1) summary
    pfam01237
    Location:158539
    Oxysterol_BP; Oxysterol-binding protein
  19. XM_030246388.1XP_030102248.1  oxysterol-binding protein 2 isoform X23

    Conserved Domains (1) summary
    pfam01237
    Location:263638
    Oxysterol_BP; Oxysterol-binding protein
  20. XM_030246387.1XP_030102247.1  oxysterol-binding protein 2 isoform X22

    Conserved Domains (1) summary
    pfam01237
    Location:263639
    Oxysterol_BP; Oxysterol-binding protein
  21. XM_011243768.4XP_011242070.1  oxysterol-binding protein 2 isoform X15

    Conserved Domains (1) summary
    pfam01237
    Location:266647
    Oxysterol_BP; Oxysterol-binding protein
  22. XM_011243766.4XP_011242068.1  oxysterol-binding protein 2 isoform X13

    Conserved Domains (1) summary
    pfam01237
    Location:270651
    Oxysterol_BP; Oxysterol-binding protein
  23. XM_017314809.1XP_017170298.1  oxysterol-binding protein 2 isoform X21

    Conserved Domains (1) summary
    pfam01237
    Location:255636
    Oxysterol_BP; Oxysterol-binding protein
  24. XM_030246384.1XP_030102244.1  oxysterol-binding protein 2 isoform X17

    Conserved Domains (1) summary
    pfam01237
    Location:264644
    Oxysterol_BP; Oxysterol-binding protein
  25. XM_030246385.1XP_030102245.1  oxysterol-binding protein 2 isoform X18

    Conserved Domains (1) summary
    pfam01237
    Location:267642
    Oxysterol_BP; Oxysterol-binding protein
  26. XM_030246386.1XP_030102246.1  oxysterol-binding protein 2 isoform X20

    Conserved Domains (1) summary
    pfam01237
    Location:264639
    Oxysterol_BP; Oxysterol-binding protein
  27. XM_006514860.4XP_006514923.1  oxysterol-binding protein 2 isoform X19

    Conserved Domains (1) summary
    pfam01237
    Location:264640
    Oxysterol_BP; Oxysterol-binding protein
  28. XM_030246383.1XP_030102243.1  oxysterol-binding protein 2 isoform X16

    Conserved Domains (1) summary
    pfam01237
    Location:264645
    Oxysterol_BP; Oxysterol-binding protein
  29. XM_011243767.3XP_011242069.1  oxysterol-binding protein 2 isoform X14

    Conserved Domains (1) summary
    pfam01237
    Location:267648
    Oxysterol_BP; Oxysterol-binding protein