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Kcmf1 potassium channel modulatory factor 1 [ Mus musculus (house mouse) ]

Gene ID: 74287, updated on 17-Aug-2024

Summary

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Official Symbol
Kcmf1provided by MGI
Official Full Name
potassium channel modulatory factor 1provided by MGI
Primary source
MGI:MGI:1921537
See related
Ensembl:ENSMUSG00000055239 AllianceGenome:MGI:1921537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pmcf; Debt91; 1700094M07Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in synaptic signaling. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human KCMF1 (potassium channel modulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 46.7), ovary adult (RPKM 17.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C1; 6 32.3 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72818097..72876962, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72841114..72899979, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene transcription factor 7 like 1 (T cell specific, HMG box) Neighboring gene predicted gene, 31391 Neighboring gene VISTA enhancer mm1474 Neighboring gene 60S ribosomal protein L37 pseudogene Neighboring gene predicted gene, 31249 Neighboring gene STARR-seq mESC enhancer starr_16313 Neighboring gene STARR-seq mESC enhancer starr_16315 Neighboring gene STARR-seq mESC enhancer starr_16319 Neighboring gene STARR-seq mESC enhancer starr_16322 Neighboring gene STARR-seq mESC enhancer starr_16325 Neighboring gene STARR-seq mESC enhancer starr_16327 Neighboring gene STARR-seq mESC enhancer starr_16328 Neighboring gene STARR-seq mESC enhancer starr_16329 Neighboring gene nuclear encoded tRNA serine 9 (anticodon GCT) Neighboring gene thymosin beta 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis. Li Z, et al. Biochem Biophys Res Commun, 2003 Jul 4. PMID 12810064
  2. The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Beilke S, et al. Oncogene, 2010 Jul 15. PMID 20473331
  3. Cerebellar development transcriptome database (CDT-DB): profiling of spatio-temporal gene expression during the postnatal development of mouse cerebellum. Sato A, et al. Neural Netw, 2008 Oct. PMID 18603407
  4. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article
  5. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCMF1 mediates pro-oncogenic functions in vitro and in vivo and downregulation of KCMF1 results in the inhibition of pancreatic cancer formation in mice
    Title: The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice.
  2. Data suggest that Debt91 is an immediate early gene up-regulated during growth factor-induced branching tubulogenesis.
    Title: Debt91, a putative zinc finger protein differentially expressed during epithelial morphogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase KCMF1
Names
RING-type E3 ubiquitin transferase KCMF1
clone DEBT-91
debt-91
differentially expressed in branching tubulogenesis 91
potassium channel modulatory factor DEBT-91
NP_001334160.1
NP_062689.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347231.1 → NP_001334160.1  E3 ubiquitin-protein ligase KCMF1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC153613
    Consensus CDS
    CCDS85066.1
    UniProtKB/TrEMBL
    A0A0N4SV15
    Related
    ENSMUSP00000144910.2, ENSMUST00000204598.3
    Conserved Domains (1) summary
    pfam05605
    Location:26 → 85
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

  2. NM_019715.2 → NP_062689.2  E3 ubiquitin-protein ligase KCMF1 isoform 1

    See identical proteins and their annotated locations for NP_062689.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153613, AK142436, CX734813
    Consensus CDS
    CCDS39518.1
    UniProtKB/Swiss-Prot
    Q80UY2, Q9WUM2
    Related
    ENSMUSP00000064410.9, ENSMUST00000068697.11
    Conserved Domains (3) summary
    cd02338
    Location:7 → 55
    ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...
    pfam05605
    Location:76 → 137
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
    pfam14571
    Location:280 → 328
    Di19_C; Stress-induced protein Di19, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72818097..72876962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UY2.1 GenPept UniProtKB/Swiss-Prot:Q80UY2

Gene LinkOut

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