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Chic2 cysteine-rich hydrophobic domain 2 [ Mus musculus (house mouse) ]

Gene ID: 74277, updated on 12-May-2024


Official Symbol
Chic2provided by MGI
Official Full Name
cysteine-rich hydrophobic domain 2provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000029229 AllianceGenome:MGI:1921527
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BTL; 1700081B18Rik; 4930502K01Rik
Predicted to act upstream of or within Golgi to plasma membrane transport. Located in Golgi apparatus; Golgi-associated vesicle; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and liver and biliary system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human CHIC2 (cysteine rich hydrophobic domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in limb E14.5 (RPKM 6.2), bladder adult (RPKM 6.0) and 28 other tissues See more
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Genomic context

See Chic2 in Genome Data Viewer
5 C3.3; 5 39.54 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (75165665..75205302, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (75005004..75044641, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6116 Neighboring gene predicted gene, 52778 Neighboring gene STARR-seq mESC enhancer starr_13415 Neighboring gene predicted gene, 52777 Neighboring gene retinoblastoma binding protein 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3584 Neighboring gene STARR-positive B cell enhancer ABC_E9644 Neighboring gene GS homeobox 2

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
Process Evidence Code Pubs
acts_upstream_of_or_within Golgi to plasma membrane transport TAS
Traceable Author Statement
more info
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
is_active_in Golgi-associated vesicle IBA
Inferred from Biological aspect of Ancestor
more info
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
located_in membrane IEA
Inferred from Electronic Annotation
more info
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane IDA
Inferred from Direct Assay
more info
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
cysteine-rich hydrophobic domain-containing protein 2
cysteine-rich hydrophobic domain 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028850.5NP_083126.1  cysteine-rich hydrophobic domain-containing protein 2

    See identical proteins and their annotated locations for NP_083126.1

    Status: VALIDATED

    Source sequence(s)
    AC161192, AK006962, AK015681, CF744991
    Consensus CDS
    Q0VG23, Q3T9U2, Q80ZT7, Q9D9G3
    ENSMUSP00000074903.6, ENSMUST00000075452.7
    Conserved Domains (1) summary
    Erf4; Golgin subfamily A member 7/ERF4 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000071.7 Reference GRCm39 C57BL/6J

    75165665..75205302 complement
    GenBank, FASTA, Sequence Viewer (Graphics)