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Usp20 ubiquitin specific peptidase 20 [ Mus musculus (house mouse) ]

Gene ID: 74270, updated on 22-Jan-2023

Summary

Official Symbol
Usp20provided by MGI
Official Full Name
ubiquitin specific peptidase 20provided by MGI
Primary source
MGI:MGI:1921520
See related
Ensembl:ENSMUSG00000026854 AllianceGenome:MGI:1921520
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vdu2; 1700055M05Rik
Summary
Predicted to enable G protein-coupled receptor binding activity; cysteine-type endopeptidase activity; and thiol-dependent deubiquitinase. Predicted to be involved in protein K48-linked deubiquitination; protein K63-linked deubiquitination; and regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within endocytosis and proteolysis. Predicted to be located in centrosome. Predicted to be active in cytoplasm. Is expressed in ganglia; retina; and trigeminal nerve. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 28.5), genital fat pad adult (RPKM 18.2) and 28 other tissues See more
Orthologs
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Genomic context

See Usp20 in Genome Data Viewer
Location:
2; 2 B
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30872291..30912667)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30982279..31022655)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene torsin family 1, member B Neighboring gene torsin family 1, member A (torsin A) Neighboring gene cDNA sequence BC005624 Neighboring gene predicted gene, 39786 Neighboring gene formin binding protein 1 Neighboring gene RIKEN cDNA D330023K18 gene Neighboring gene G protein-coupled receptor 107

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (5)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 20
Names
VHL-interacting deubiquitinating enzyme 2
deubiquitinating enzyme 20
ubiquitin specific protease 20
ubiquitin thioesterase 20
ubiquitin thiolesterase 20
ubiquitin-specific-processing protease 20
NP_083122.1
XP_030107995.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028846.5NP_083122.1  ubiquitin carboxyl-terminal hydrolase 20

    See identical proteins and their annotated locations for NP_083122.1

    Status: VALIDATED

    Source sequence(s)
    AK047242, AK054279, AK173083, BY251374
    Consensus CDS
    CCDS15893.1
    UniProtKB/Swiss-Prot
    Q8C6M1, Q8CJ72
    Related
    ENSMUSP00000099913.5, ENSMUST00000102849.11
    Conserved Domains (4) summary
    smart00695
    Location:812896
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:73688
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:145684
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30872291..30912667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252135.1XP_030107995.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    UniProtKB/Swiss-Prot
    Q8CJ72
    Conserved Domains (4) summary
    smart00695
    Location:812896
    DUSP; Domain in ubiquitin-specific proteases
    COG5560
    Location:73688
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:145684
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:3090
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein