KSR2 kinase suppressor of ras 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: KSR2provided by VGNC
Official Full Name: kinase suppressor of ras 2provided by VGNC
Primary source: VGNC:VGNC:52057
Locus tag: CK820_G0021748
See related: Ensembl:ENSPTRG00000005507
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	10	NC_072408.2 (124267201..124773330, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	12	NC_072410.1 (122863967..123384067, complement)

Chromosome 10 - NC_072408.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D12S1974 (e-PCR)
- UniSTS:54290

G17626 (e-PCR)
- UniSTS:11549

D8S2109 (e-PCR)
- UniSTS:67878

D12S1720 (e-PCR)
- UniSTS:50222

WI-7483 (e-PCR)
- UniSTS:66869

SHGC-149743 (e-PCR)
- UniSTS:182581

SHGC-110724 (e-PCR)
- UniSTS:167990

SHGC-111879 (e-PCR)
- UniSTS:168798

G64754 (e-PCR)
- UniSTS:164714

G64753 (e-PCR)
- UniSTS:164739

SHGC-151170 (e-PCR)
- UniSTS:173458

G64589 (e-PCR)
- UniSTS:163732

D12S810 (e-PCR)
- UniSTS:149148

G64843 (e-PCR)
- UniSTS:164768

SHGC-144516 (e-PCR)
- UniSTS:174264

SHGC-144921 (e-PCR)
- UniSTS:174325

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: kinase suppressor of Ras 2

XP_009424624.1

EC 2.7.11.1

XP_063641101.1

EC 2.7.11.1

XP_063641102.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072408.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

124267201..124773330 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009426349.5 → XP_009424624.1 kinase suppressor of Ras 2 isoform X3

See identical proteins and their annotated locations for XP_009424624.1

UniProtKB/TrEMBL

A0A2J8ME31, A0A2J8ME36

Conserved Domains (3) summary

cd00029
Location:413 → 455

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd14153
Location:663 → 932

PK_KSR2; Pseudokinase domain of Kinase Suppressor of Ras 2

pfam13543
Location:24 → 152

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1
XM_063785031.1 → XP_063641101.1 kinase suppressor of Ras 2 isoform X1

UniProtKB/TrEMBL

A0A2J8ME28, A0A6D2WK51, H2Q6Z2
XM_063785032.1 → XP_063641102.1 kinase suppressor of Ras 2 isoform X2