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VGF VGF nerve growth factor inducible [ Homo sapiens (human) ]

Gene ID: 7425, updated on 1-Jun-2020

Summary

Official Symbol
VGFprovided by HGNC
Official Full Name
VGF nerve growth factor inducibleprovided by HGNC
Primary source
HGNC:HGNC:12684
See related
Ensembl:ENSG00000128564 MIM:602186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCG7; SgVII
Summary
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 14.2) and fat (RPKM 1.5) See more
Orthologs

Genomic context

See VGF in Genome Data Viewer
Location:
7q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (101162509..101169956, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100805790..100810862, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 5920 Neighboring gene adaptor related protein complex 1 subunit sigma 1 Neighboring gene microRNA 4653 Neighboring gene N-acetyltransferase 16 (putative) Neighboring gene monoacylglycerol O-acyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbohydrate homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
insulin secretion IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
regulation of synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to cold IEA
Inferred from Electronic Annotation
more info
 
response to dietary excess IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
sexual reproduction IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
neurosecretory protein VGF
Names
neuro-endocrine specific protein VGF

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003378.4NP_003369.2  neurosecretory protein VGF precursor

    See identical proteins and their annotated locations for NP_003369.2

    Status: REVIEWED

    Source sequence(s)
    BC036537, BC063835
    Consensus CDS
    CCDS5712.1
    UniProtKB/Swiss-Prot
    O15240
    Related
    ENSP00000249330.2, ENST00000249330.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    101162509..101169956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516549.3XP_011514851.1  neurosecretory protein VGF isoform X1

    See identical proteins and their annotated locations for XP_011514851.1

    UniProtKB/Swiss-Prot
    O15240
  2. XM_005250561.5XP_005250618.1  neurosecretory protein VGF isoform X1

    See identical proteins and their annotated locations for XP_005250618.1

    UniProtKB/Swiss-Prot
    O15240
    Related
    ENSP00000400884.2, ENST00000445482.2
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