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Gale galactose-4-epimerase, UDP [ Mus musculus (house mouse) ]

Gene ID: 74246, updated on 26-Sep-2022

Summary

Official Symbol
Galeprovided by MGI
Official Full Name
galactose-4-epimerase, UDPprovided by MGI
Primary source
MGI:MGI:1921496
See related
Ensembl:ENSMUSG00000028671 AllianceGenome:MGI:1921496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310002A12Rik
Summary
Enables UDP-glucose 4-epimerase activity. Acts upstream of or within galactose metabolic process. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in galactose epimerase deficiency. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 100.7), large intestine adult (RPKM 78.5) and 22 other tissues See more
Orthologs
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Genomic context

See Gale in Genome Data Viewer
Location:
4; 4 D3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135690550..135695489)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135963681..135968178)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene fucosidase, alpha-L- 1, tissue Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A lyase Neighboring gene lysophospholipase 2 Neighboring gene PITH (C-terminal proteasome-interacting domain of thioredoxin-like) domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
 
enables UDP-glucose 4-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables UDP-glucose 4-epimerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables UDP-glucose 4-epimerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables UDP-glucose 4-epimerase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UDP-glucose 4-epimerase
Names
UDP-GalNAc 4-epimerase
UDP-GlcNAc 4-epimerase
UDP-N-acetylglucosamine 4-epimerase
UDP-galactosamine 4-epimerase
UDP-galactose 4-epimerase
galactowaldenase
NP_001343422.1
XP_006539281.1
XP_006539282.1
XP_030109702.1
XP_030109703.1
XP_030109704.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356493.1NP_001343422.1  UDP-glucose 4-epimerase

    Status: VALIDATED

    Source sequence(s)
    AI847878, AL672076, AW544394, BB854114, BG077710, CO429161
    Consensus CDS
    CCDS18796.1
    UniProtKB/Swiss-Prot
    Q8R059
    Related
    ENSMUSP00000099600.4, ENSMUST00000102541.10
    Conserved Domains (1) summary
    cd05247
    Location:3337
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135690550..135695489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253842.2XP_030109702.1  UDP-glucose 4-epimerase isoform X2

    Conserved Domains (1) summary
    cd05247
    Location:1220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
  2. XM_006539219.5XP_006539282.1  UDP-glucose 4-epimerase isoform X1

    See identical proteins and their annotated locations for XP_006539282.1

    UniProtKB/Swiss-Prot
    Q8R059
    Conserved Domains (1) summary
    cd05247
    Location:3337
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
  3. XM_006539218.5XP_006539281.1  UDP-glucose 4-epimerase isoform X1

    See identical proteins and their annotated locations for XP_006539281.1

    UniProtKB/Swiss-Prot
    Q8R059
    Conserved Domains (1) summary
    cd05247
    Location:3337
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
  4. XM_030253843.2XP_030109703.1  UDP-glucose 4-epimerase isoform X2

    Conserved Domains (1) summary
    cd05247
    Location:1220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
  5. XM_030253844.2XP_030109704.1  UDP-glucose 4-epimerase isoform X2

    Conserved Domains (1) summary
    cd05247
    Location:1220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

RNA

  1. XR_003955031.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178389.3: Suppressed sequence

    Description
    NM_178389.3: This RefSeq was removed because currently there is insufficient support for the transcript.