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Atg7 autophagy related 7 [ Mus musculus (house mouse) ]

Gene ID: 74244, updated on 10-Jun-2024

Summary

Official Symbol
Atg7provided by MGI
Official Full Name
autophagy related 7provided by MGI
Primary source
MGI:MGI:1921494
See related
Ensembl:ENSMUSG00000030314 AllianceGenome:MGI:1921494
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Agp7; Apg7l; Atg7l; Gm21553; 1810013K23Rik
Summary
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 13.1), testis adult (RPKM 12.7) and 28 other tissues See more
Orthologs
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Genomic context

See Atg7 in Genome Data Viewer
Location:
6; 6 E3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (114620075..114837565)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (114643127..114860604)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38875 Neighboring gene histamine receptor H1 Neighboring gene STARR-positive B cell enhancer ABC_E9098 Neighboring gene STARR-seq mESC enhancer starr_17063 Neighboring gene STARR-seq mESC enhancer starr_17064 Neighboring gene predicted gene, 52917 Neighboring gene STARR-positive B cell enhancer ABC_E11331 Neighboring gene calmodulin regulated spectrin-associated protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114824988-114825171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114825181-114825290 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114843851-114843960 Neighboring gene STARR-seq mESC enhancer starr_17069 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:114870691-114870844 Neighboring gene STARR-positive B cell enhancer ABC_E4855 Neighboring gene STARR-positive B cell enhancer mm9_chr6:114872780-114873081 Neighboring gene vestigial like family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E4856 Neighboring gene STARR-seq mESC enhancer starr_17074 Neighboring gene predicted gene, 38876 Neighboring gene predicted gene, 52944

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Atg12 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Atg12 activating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Atg12 activating enzyme activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables Atg12 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
enables Atg8 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables Atg8 activating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in C-terminal protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within autophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hyperoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cellular response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to sodium arsenite ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular amino acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular sphingolipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative stranded viral RNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organelle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in piecemeal microautophagy of the nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein modification process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein modification process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein lipidation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein modification by small protein conjugation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pyramidal neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic vesicle cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type B pancreatic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axoneme IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dopaminergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dopaminergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-like modifier-activating enzyme ATG7
Names
ATG12-activating enzyme E1 ATG7
autophagy-related protein 7
ubiquitin-activating enzyme E1-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253717.2NP_001240646.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 1

    See identical proteins and their annotated locations for NP_001240646.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122843, AC149276, AC170088
    Consensus CDS
    CCDS59697.1
    UniProtKB/TrEMBL
    A0A0A0MQN4, Q3TAB9, Q3TM87
    Related
    ENSMUSP00000133215.4, ENSMUST00000169310.10
    Conserved Domains (3) summary
    cd01486
    Location:396720
    Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
    TIGR01381
    Location:54740
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    pfam16420
    Location:52359
    ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
  2. NM_001253718.2NP_001240647.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 2

    See identical proteins and their annotated locations for NP_001240647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 5' coding region, resulting in initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC122843, AC149276, AC170088
    Consensus CDS
    CCDS39598.1
    UniProtKB/Swiss-Prot
    Q3TCD9, Q8K4Q5, Q9D906
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Related
    ENSMUSP00000138137.2, ENSMUST00000182793.8
    Conserved Domains (1) summary
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
  3. NM_001379130.1NP_001366059.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122843, AC149276, AC170088
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Conserved Domains (1) summary
    TIGR01381
    Location:27713
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
  4. NM_028835.5NP_083111.1  ubiquitin-like modifier-activating enzyme ATG7 isoform 2

    See identical proteins and their annotated locations for NP_083111.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, resulting in the initiation of translation from a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC122843, AC149276, AC170088
    Consensus CDS
    CCDS39598.1
    UniProtKB/Swiss-Prot
    Q3TCD9, Q8K4Q5, Q9D906
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Related
    ENSMUSP00000032457.10, ENSMUST00000032457.17
    Conserved Domains (1) summary
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p

RNA

  1. NR_166516.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122843, AC149276, AC170088

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    114620075..114837565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152367.1XP_036008260.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TCD9, Q8K4Q5, Q9D906
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Conserved Domains (1) summary
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
  2. XM_036152368.1XP_036008261.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TCD9, Q8K4Q5, Q9D906
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Related
    ENSMUSP00000138779.2, ENSMUST00000182428.8
    Conserved Domains (1) summary
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
  3. XM_036152370.1XP_036008263.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TCD9, Q8K4Q5, Q9D906
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Conserved Domains (1) summary
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
  4. XM_036152369.1XP_036008262.1  ubiquitin-like modifier-activating enzyme ATG7 isoform X1

    UniProtKB/Swiss-Prot
    Q3TCD9, Q8K4Q5, Q9D906
    UniProtKB/TrEMBL
    Q3TAB9, Q3TM87
    Related
    ENSMUSP00000138651.2, ENSMUST00000182902.8
    Conserved Domains (1) summary
    TIGR01381
    Location:11697
    E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p