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Iqce IQ motif containing E [ Mus musculus (house mouse) ]

Gene ID: 74239, updated on 26-Sep-2022

Summary

Official Symbol
Iqceprovided by MGI
Official Full Name
IQ motif containing Eprovided by MGI
Primary source
MGI:MGI:1921489
See related
Ensembl:ENSMUSG00000036555 AllianceGenome:MGI:1921489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1023; 1700028P05Rik
Summary
Involved in positive regulation of transcription by RNA polymerase II. Located in ciliary membrane. Is extrinsic component of membrane. Part of plasma membrane protein complex. Orthologous to human IQCE (IQ motif containing E). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.3), CNS E18 (RPKM 6.5) and 24 other tissues See more
Orthologs
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Genomic context

See Iqce in Genome Data Viewer
Location:
5; 5 G2
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (140648308..140688158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (140662553..140702403, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene tweety family member 3 Neighboring gene BRCA1-associated ATM activator 1 Neighboring gene archaelysin family metallopeptidase 1 Neighboring gene predicted gene, 30745

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of plasma membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
IQ domain-containing protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347517.1NP_001334446.1  IQ domain-containing protein E isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and lacks another alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC110253
    Consensus CDS
    CCDS84987.1
    UniProtKB/Swiss-Prot
    Q6PCQ0
    Related
    ENSMUSP00000077050.6, ENSMUST00000077890.12
  2. NM_028833.3NP_083109.2  IQ domain-containing protein E isoform 1

    See identical proteins and their annotated locations for NP_083109.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC110253
    Consensus CDS
    CCDS39358.1
    UniProtKB/Swiss-Prot
    Q6PCQ0, Q9D9U3
    Related
    ENSMUSP00000045913.8, ENSMUST00000041783.14
    Conserved Domains (2) summary
    smart00015
    Location:553573
    IQ; Calmodulin-binding motif
    pfam01486
    Location:399476
    K-box; K-box region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    140648308..140688158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254853.1XP_030110713.1  IQ domain-containing protein E isoform X7

    Conserved Domains (2) summary
    COG1196
    Location:167436
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:93693
    CCDC158; Coiled-coil domain-containing protein 158
  2. XM_006504742.4XP_006504805.1  IQ domain-containing protein E isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:448765
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:167436
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. XM_036165559.1XP_036021452.1  IQ domain-containing protein E isoform X10

    Conserved Domains (3) summary
    PLN03209
    Location:469708
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00015
    Location:451471
    IQ; Calmodulin-binding motif
    COG1196
    Location:167453
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  4. XM_006504741.4XP_006504804.1  IQ domain-containing protein E isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:475792
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:380461
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  5. XM_006504744.4XP_006504807.1  IQ domain-containing protein E isoform X5

    Conserved Domains (3) summary
    PLN03209
    Location:514753
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00015
    Location:496516
    IQ; Calmodulin-binding motif
    COG1196
    Location:212498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  6. XM_006504745.4XP_006504808.1  IQ domain-containing protein E isoform X9

    Conserved Domains (2) summary
    smart00015
    Location:553573
    IQ; Calmodulin-binding motif
    COG1196
    Location:212481
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  7. XM_006504740.4XP_006504803.1  IQ domain-containing protein E isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:493805
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:212565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  8. XM_006504739.4XP_006504802.1  IQ domain-containing protein E isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:493810
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:212565
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  9. XM_006504746.4XP_006504809.1  IQ domain-containing protein E isoform X14

    Conserved Domains (2) summary
    PHA03247
    Location:254571
    PHA03247; large tegument protein UL36; Provisional
    TIGR02169
    Location:18241
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  10. XM_030254857.1XP_030110717.1  IQ domain-containing protein E isoform X14

    Conserved Domains (2) summary
    PHA03247
    Location:254571
    PHA03247; large tegument protein UL36; Provisional
    TIGR02169
    Location:18241
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  11. XM_036165558.1XP_036021451.1  IQ domain-containing protein E isoform X8

    Conserved Domains (2) summary
    smart00015
    Location:496516
    IQ; Calmodulin-binding motif
    COG1196
    Location:212498
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  12. XM_030254859.2XP_030110719.1  IQ domain-containing protein E isoform X18

    Conserved Domains (3) summary
    PHA03247
    Location:185502
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:90171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:61257
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  13. XM_030254858.1XP_030110718.1  IQ domain-containing protein E isoform X16

    Conserved Domains (4) summary
    smart00015
    Location:314334
    IQ; Calmodulin-binding motif
    PHA03307
    Location:239512
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:4242
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22307
    Location:201343
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
  14. XM_030254856.1XP_030110716.1  IQ domain-containing protein E isoform X13

    Conserved Domains (2) summary
    COG1196
    Location:102371
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:28628
    CCDC158; Coiled-coil domain-containing protein 158
  15. XM_030254855.1XP_030110715.1  IQ domain-containing protein E isoform X12

    Conserved Domains (3) summary
    PLN03209
    Location:449688
    PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
    smart00015
    Location:431451
    IQ; Calmodulin-binding motif
    COG1196
    Location:147433
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  16. XM_030254854.1XP_030110714.1  IQ domain-containing protein E isoform X11

    Conserved Domains (2) summary
    COG1196
    Location:147416
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15921
    Location:73673
    CCDC158; Coiled-coil domain-containing protein 158
  17. XM_030254852.1XP_030110712.1  IQ domain-containing protein E isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:428745
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:147416
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  18. XM_036165562.1XP_036021455.1  IQ domain-containing protein E isoform X16

    Conserved Domains (4) summary
    smart00015
    Location:314334
    IQ; Calmodulin-binding motif
    PHA03307
    Location:239512
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:4242
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd22307
    Location:201343
    Adgb_C_mid-like; C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif
  19. XM_036165560.1XP_036021453.1  IQ domain-containing protein E isoform X15

    Conserved Domains (3) summary
    PHA03247
    Location:236553
    PHA03247; large tegument protein UL36; Provisional
    COG1196
    Location:141222
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:112308
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
  20. XM_006504748.2XP_006504811.1  IQ domain-containing protein E isoform X17

    Conserved Domains (2) summary
    PHA03247
    Location:217534
    PHA03247; large tegument protein UL36; Provisional
    TIGR02169
    Location:10204
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type