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Septin14 septin 14 [ Mus musculus (house mouse) ]

Gene ID: 74222, updated on 30-Apr-2024

Summary

Official Symbol
Septin14provided by MGI
Official Full Name
septin 14provided by MGI
Primary source
MGI:MGI:1921472
See related
Ensembl:ENSMUSG00000034219 AllianceGenome:MGI:1921472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sept14; 1700016K13Rik
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Involved in neuron migration. Located in several cellular components, including dendrite; perikaryon; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SEPTIN14 (septin 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 2.8) See more
Orthologs
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Genomic context

See Septin14 in Genome Data Viewer
Location:
5 G1.3; 5 68.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129760455..129782048, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129683391..129704984, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene shugoshin-like 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14454 Neighboring gene zinc finger protein 11 Neighboring gene STARR-seq mESC enhancer starr_14455 Neighboring gene STARR-positive B cell enhancer ABC_E11303 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:130230774-130230883 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene nipsnap homolog 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028826.2NP_083102.1  septin-14

    Status: VALIDATED

    Source sequence(s)
    AC120413
    Consensus CDS
    CCDS59685.1
    UniProtKB/Swiss-Prot
    E9QMM2, Q9DA97
    UniProtKB/TrEMBL
    S4R2P6
    Related
    ENSMUSP00000138729.2, ENSMUST00000182386.3
    Conserved Domains (2) summary
    cd01850
    Location:48314
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:33386
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129760455..129782048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)